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Article
Serum Anti-Cyclic Citrullinated Peptide (Anti_CCP) Antibody Level in Rheumatoid Arthritic Patients with and without Nodal Osteoarthritis

Author: Ahmed A. Gassid
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 2 Pages: 151-156
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Rheumatoid Arthritis (RA) is chronic systemic inflammatory disease affects synovial joints , articular structures and extra articular , the prevalence rate occurs aprox in about 1% of population Anti citrullinated peptide/protein antibody (Anti-CCP) antibody are autoantibodies(antibodies directed against one or more of the individuals own proteins) frequently detected in RA patients during inflammation. citrulline is incorporated enzymatically into proteins .The current study is a trail to ensure that Anti-CCP marker is more specific and sensitive for diagnosis of RA patients and to detect the effect of the presence of other disease like NOA on Anti-CCP valueOBJECTIVE:Evaluation of Anti-CCP Ab level in RA patients with and without NOA.The serum level of Accp_Ab is estimated using ELISA technique in patients with RA and NOA.SUBJECTS AND METHODS:The studied group includes 30 RA patients (24 females and 6 males), who fulfilled four or more of the 1987 ACR criteria compared with 30 RA+NOA patients (23 females and 7 males) also fulfilled four or more of the 1987 ACR criteria for the classification of Rheumatoid arthritis and nodal osteoarthritis group. Blood samples were taken from three groups to analyze and measure the serum levels of Anti-CCP.RESULTS:Result of investigations were compared with that for the 30 apparently healthy control individuals who matched the patient´s group in age and sex.The result of the study showed that majority of patients is females (80%) for RA patients and (76.6%) for RA+NOA patients (with females: males 4:1 & 3.28:1 for RA and RA+NOA respectively). Moreover, the mean age for RA, RA+NOA and control groups are: 48.03±12.95y, 51.3±11.8y and 37.43±12.57years respectively.It was observed from the result that there is a higher positivity of Anti-CCP in the patients sera( 76.7% for RA+NOA cases and 70% for RA cases) in comparison with healthy control group (0.0%) so there is highly significant difference (p<0.001).While the quantitative estimation of Anti-CCP antibodies showed that its level was higher among sera of RA+NOA patients in addition to RA patients (53.59±33.29 RU/ml and 52.28±48.99 RU/ml respectively) in comparison with healthy control group 2.88±2.50 RU/ml.CONCLUSION:We found that Anti-CCP is a good & specific marker for diagnosis of RA & RA can be differentiated from other disease by measuring this marker.Moreover, Anti-CCP Ab level in RA patients does not significantly affected by the presence of NOA.


Article
Evaluationof Highly Sensitive C-Reactive Protein in Female Patients with Nodal Osteoarthritis

Authors: Ammar W. Obeid --- Munaf S. Daoud --- Mohammed H. Alosami
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 4 Pages: 479-484
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Nodal Osteoarthritis is a subset of OA characterized by polyarticularinterphalangeal and thumb base OA ,Heberden’sand Bouchard’s nodes formation.C-reactive protein (CRP) is one of the first acute phase response proteins to be elevated in an inflammatory processes.OBJECTIVE:The aim of this study is to investigate whether the inflammatory processes have roles in the development of nodal osteoarthritis (NOA) in Iraqi femalepatients using serum highly sensitive C-reactive protein as aninflammatory marker.SUBJECTS AND METHODS:The study included eighty four females, divided into two main groups,sixty were patients with (NOA), and twenty-four represented the control group. Other subdivisions were applied according to body mass index and menopause status. Measurement of serum (hsCRP), wasapplied to all subjects included in this study, by ELISA sandwich method.RESULTS:Serum highly sensitive C-reactive protein (hsCRP) level was significantly higher (18.08±8.15) (P value < 0.05) in patients with NOA in comparison to control group (2.23±1.73) .CONCLUSION:Highly significant elevated level of serum (hsCRP) observed in the NOA patients compared to control suggest that the inflammatory processes have roles in the development of NOA.


Article
Estimation of serum leptin in female patients with nodal osteoarthritis

Author: Raid D. Hashim * MBChB د. رائد هاشم
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 4 Pages: 392-394
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Nodal osteoarthritis is one of the most common arthropathy worldwide, the etiology is uncertain but many biochemical markers are recognized. Many studies have shown that leptin might have a role in the pathogenesis of osteoarthritis, but little is known about the relation between serum leptin and nodal osteoarthritis. Subjects and method: 52 women with nodal osteoarthritis and 40 apparently healthy women as a control were included in the study; serum leptin was measured in all subjects. Student t-test was applied to find out the significance of difference in the mean v Results: There was a significant difference in the mean of serum leptin between patients and control groups.Conclusion: the results of the current study suggest that leptin might have a role in the pathogenesis of nodal osteoarthritisKeywords: leptin, nodal osteoarthritis, pathogenesis, Body Mass Index.


Article
Evaluation of Serum Adiponectin and Bone Mineral Density in Nodal osteoarthritis patients
تقييم الاديبونكتين في المصل وكثافة كتلة العظم في مرضى الفصال العظمي العقدي

Authors: Adnan F Al-Najar د.عدنان فاضل النجار --- Abbas Toma د.عباس طعمه --- Mustafa Saleam د. مصطفى سالم
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2015 Volume: 28 Issue: 2 Pages: 66-70
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Many studies have explain that adiponectin have an important role in the pathogenesis of osteoarthritis, but little is known about the relation between serum adiponectin and nodal osteoarthritis.Subjects and methods: Sixty Nodal osteoarthritis patients (male and female) and60 controls (male and female) included in the study; serum adiponectin and Bone mineral density (T-score) were measured in all subjects. Student t-test was applied to find out the significance of difference between two means.Results: Significant increase in the mean of serum adiponectin and significant decrease in the Bone mineral density (T-score) between Nodal osteoarthritis patients and control groups have been found. Also significantly increase in the mean of serum adiponectin between Nodal osteoarthritis patients according to Bone mineral density.Conclusion: The results of the current study suggest that adiponectin might have a role in the pathogenesis of NOA and osteoporosis.

هدف البحث : الفصال العظمي العقدي هو نوع من التهاب المفاصل ومشهور في جميع أنحاء العالم، والمسببات غير معروف ولكن هناك علامات بيوكيميائية تميزه. العديد من الدراسات توضح أن الاديبونيكتين في مصل الدم يكون له دور مهم في اسباب المرض في الفصال العظمي العقدي، ولكن لا يعرف الكثير عن العلاقة بين الاديبونيكتين في مصل الدم ومرضى الفصال العظمي العقدي. المرضى وطريقة العمل : 60 من مرضى الفصال العظمي العقدي (نساء ورجال) و 60 الأصحاء (نساء ورجال) تضمنت في الدراسة؛ تم قياس الاديبونيكتين في مصل الدم كثافة كتلة العظم في جميع العناصر المتضمنه .تطبيق اختبار ال T-test لمعرفة أهمية الفرق بين معدلين .النتائج: زيادة كبيرة في متوسط اديبونيكتين في المصل وانخفاض ملحوظ في كثافة معدن العظم بين مرضى الفصال العظمي العقدي والأصحاء . أيضا زيادة كبيرة في متوسط اديبونيكتين في الدم بين المرضى الفصال العظمي العقدي وفقاً لكثافة معادن العظم. الاستنتاج: نتائج الدراسة الحالية تشير إلى أن اديبونيكتين قد يكون له دور في الاصابة بمرض الفصال العظمي العقدي وهشاشة العظام. وهناك علاقة معقدة إحصائية بين الاديبونكتين ومرض الفصال العظمي العقدي

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