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Extraction and Evaluation the Activity of Urtica dioica as Bleeding Stop Material

Author: Hashim M. Zehraw , Zynab Muotaz , Muamer Taleb , Bydaa Mukhlif , Saad Abed Al-Jabbar
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2019 Volume: 18 Issue: 2 Pages: 77-87
Publisher: Baghdad University جامعة بغداد

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Abstract

Urtica dioica From the medicinal herbs group, with many uses, the extract of the plant was prepared in order to study effect on the process of stopping hemorrhage of various pathological causes, collection of plants in the pre-blooming phase of the Jadiriyah area, Baghdad, Iraq. Prepare a sample of it by way of alcohol extraction for all parts of the plant. The substances and active groups were identified using chemical analysis. The results showed the presence of the necessary phytol in the blood clotting process as well as the glycosides, tannins, proteins, flavonoids and others. Some antioxidant, anti-inflammatory and anticancer compounds were found using gas chromatography technique. High-performance liquid chromatography was used as the important morphine was identified in the manufacture of a number of vitamins. The trace sample showed a high concentration of sodium and iron and a low concentration of zinc. The tested sample passed the toxicity test carried out on laboratory animals and proved its non toxic in the doses used. The results of the treatment of blood hemorrhage in mice found that the plant extract had an effect on reducing the duration of bleeding cessation to 1.14 seconds compared to the non-treated group (3.21) seconds, about 60% less, the hemoglobin level in rabbits was reduced to a significant level (P <0.01) to 13.2 g / dl compared with the control (14.5) g / dl and decreased packed cell volume (PCV) to 41 ml compared to 46 ml with control. It is noted that the number of white blood cells decreased with a significant value (P <0.01) to 5900 × 10 3 μl compared with control 8200 × 10 3 μl and found a decrease (P <0.01) at the time of bleeding by 50% after treatment with the extract and reduced the coagulation time by one third and with a significant value P <0.01).

Keywords

Urtica dioica --- Hemorrhage --- phytol --- Morin.

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