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Article
Correlation between Streptococci Mutans and salivary IgA in relation to some oral parameters in saliva of children

Authors: Lamia I. Sood --- Minan Y. H. Al-Ezzy --- Ameena R. Diajil
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 1 Pages: 71-79
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Saliva plays an important role in oral health. Several salivary proteins are involved in the antimicrobialdefence mechanism and are able to eliminate or inhibit bacterial growth in the oral cavity. Secretory IgA (SIgA) isone of the principal antibodies present in saliva, could help oral immunity by preventing microbial adherence,neutralizing enzymes and toxins.The aim of this study was to investigate the relationship between salivary Streptococcus Mutans (SM) count and S IgAin stimulated whole saliva in children with primary dentition compared to those with permanent teeth in relation tosome oral hygiene parameters.Material and methods: Stimulated whole saliva was collected from 50 children (25 with primary dentation and 25 withpermanent teeth). Salivary flow rate and pH was measured. Oral hygiene index (OHI) and gingival inflammation wasassessed using classical method. S IgA level was measured using an immunoassay kit and SM count was determinedby culture media.Results: Mean salivary flow rate, pH and S IgA were significantly higher among children with permanent teethcompared to those with primary dentition.Compared to primary dentition, permanent dentition was associated with a significantly reduced mean plaqueindex, increased mean gingival index and reduced mean salivary SM count.Although plaque index showed a statistically significant positive correlation with SM count, gingival index showed aweak negative correlation with bacterial count.S IgA, PH and flow rate showed a statistically significant moderately strong negative correlation with bacterial count.Conclusion: This study showed a clear correlation between count of SM in stimulated whole saliva and both SIgA andplaque index


Article
Comparison of Immunoglobulin IgA Level in the Stimulated Saliva of Caries-Free and Caries-Active Children Aged 7-10 Years

Author: Heba N. Yassin هبه ياسين
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 3 Pages: 155-158
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Salivary immunoglobulin IgA plays an essential role in the immune response against dental caries. Thisstudywas conducted to compare the salivary IgA levels and flow rate of stimulated saliva in caries active and cariesfree children.Materials and methods: The present study included sixty healthy children age 7-10 yearswho were divided into twogroups. They were caries free and caries active children (30 children in each group). Assessment and recording ofcaries – experience were through the application of Decayed, Missing and Filled Tooth Index (DMFT) and (dmft)index, for permanent and deciduous teeth respectively. After dental examination, stimulated saliva samples werecollected from the subjects and performed under standard condition following instruction cited by Tenovuo andLagerlof, and chemically analyzed for the detection of salivary immunoglobulin (IgA).In addition, salivary flow rate forthe children were evaluated. Data was then statistically analyzed using SPSSversion 18.Results: Salivary IgA levels were significantly higher in caries free children than caries active children and the flow ratewere lower in caries active children in both gender as compared to caries free children.Conclusions: Within the limitation of this study, it can be concluded that that the flow rate and salivary IgA levels ofthe whole stimulated saliva have some role in protection against dental caries


Article
Study of salivary IgA concentrations, salivary flow rate in patients with β –thalassemia major in Missan Governorate

Authors: Jamal M. Diwan --- Zaheda J. Mohammad
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 3 Pages: 55-57
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Beta-thalassemia major is the most common monogenic known disorder in the Middle East,characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypesranging from severe anemia to clinically asymptomatic Individuals. This study aimed to evaluate salivary flow rateand salivary IgA in β-thalassemia major patients. Since many oral and systemic conditions manifest themselves aschanges in the flow and composition of saliva the dental practitioner is advised to remain up-to-date with this issue.Materials and methods: The study samples consist of (60) subjects, patients group composed of (30) patients with β –thalassemia major, age rang (5-23) years and (30) healthy locking subject of both sexes as control group, with agerange from (5-25) years.Results: Most patients were in the first and second decade of life (90%) this indicate a reduced life expectancy inthose patients, laboratory investigations for salivary IgA concentrations revealed a significant increase in means ofthis marker in compare with control group and this difference is statistically significant, (p= 0.05) at P value ≤0.05.Regarding the salivary flow rate there was a statistically significant decrease in mean of salivary flow rate inpatients group as compared with control group (P= 0.013).Conclusions: Beta-thalassemia major affects salivary flow rate and SIgA concentration


Article
Oral manifestations, microbial study and salivary IgA study in lymphoma patients receiving chemotherapy

Authors: Hamza W. Ahmed Al-kuhla حمزة احمد الكحلة --- Fawaz D. Al-Aswad فواز الاسود
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 1 Pages: 39-44
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Lymphoma is a general term that includes 40 different sub-types of the disease. These can be dividedinto two main types: Hodgkin Lymphoma and Non-Hodgkin lymphoma. Lymphomas are a cancer of white cellsproduced by the bone marrow and matured in the lymphatic system. The cancer may originate in the lymph glandsor organs such as the liver, spleen, bowel or bone marrow. The aims were to determine the prevalence of oralmanifestations in lymphoma patients, isolate and identify different microorganism (aerobic, anaerobic and fungi),from oral micro flora from lymphoma patients under chemotherapy and detect the level of salivary IgA incomparison with healthy control.Subjects, materials and methods: The study included 52 lymphoma patients (17 Hodgkin’s and 35 Non Hodgkin’s) ofboth sexes (27 male and 25 female) those patients were matched in age and sex with 15 healthy control subjects.Results: The most frequent oral manifestations in the lymphoma patients in this study was taste alteration (52.2%),burning mouth sensation (37.3%), dry mouth (37.3%), halitosis (16.4%) and (7.5%) white coated tongue respectively.Various species of bacteria were isolated; the main bacteria isolated were streptococcus viridians, Neisseria,Staphylococcus aureus, Staphylococcus albus, Pseudomonas, Actinomyces, Lactobacillus, Klebsiella, andEscherichia-coli and anaerobic bacteria such as Peptostreptococcus and Bacillus. Fungi such as Candida albicanswere also identified. Level of Salivary IgA was significantly decreased in lymphoma patients under treatment incomparison to healthy control.Conclusions: The finding of this study shows obvious differences in the prevalence of micro-organisms betweenlymphoma patients and healthy control. The most frequent oral manifestations in lymphoma patients were tastealterations, xerostomia, and burning mouth sensation.A significant decreased in level of salivary IgA was noticed in all lymphoma patients.It is highly recommended that all patients to have thorough dental examination before starting treatment


Article
Oral manifestations, microbial study and salivary IgA study in asthmatic patients receiving prednisolone

Authors: Mushtaq T. Ibraheem مشتاق ابراهيم --- Fawaz D. Al-Aswad فواز الاسود
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 2 Pages: 87-93
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Asthma is a disease of the airways characterized by chronic inflammation associated with airwayhyper-responsiveness and airway wall remodeling.Aims of the study: The aims of this study was to determine the prevalence of oral manifestations , identify differentmicroorganism from oral micro flora and determination of salivary IgA and salivary flow rate in asthmatic patientstaking different dose of Prednisolone in comparison with control group.Subjects, materials and methods: The study included 17 patients under treatment with Prednisolone (10-20 mg),15patients take (20-30 mg) of Prednisolone and other 18 patients take (30 – 40mg) of Prednisolone, and 25 healthycontrol group (10 male and 15 female).Results : The most frequent oral manifestations in asthmatic patients on Prednisolone was burning mouth syndrome,then dry mouth, tooth erosion and white coated tongue and decreased in salivary flow rate. High prevalence ofStaphylococcus aureus , Staphylococcus epidermidis , streptococcus Viridians and Candida albicans in patients withasthma and difference in oral microbial isolation between asthmatic patients take different dose of Prednisoloneand healthy control.The level of salivary IgA in asthmatic patients treated with Prednisolone less than healthy control.Conclusions: The findings of this study show an obvious difference in the prevalence of oral manifestation and somemicro-organisms between patients with asthma and healthy control. Decrease of IgA and salivary flow rate inpatients with asthma as compared to healthy control


Article
Evaluation of oral health status in patients receiving antiepileptic medications

Authors: Farqad Najm Abed فرقد نجم عبد --- Raja H. Al –Jubouri رجاء الجبوري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 2 Pages: 69-73
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Epilepsy is a common neurological disorder of incidence rate 1-2%. Genetic, congenital,developmental, tumors, head trauma and central nervous system infections maybe the cause of epilepsy. This studyaimed to determine the prevalence of stomatitis, xerostomia and taste disorder among patients takingcarbamazepine or sodium valproate and to make salivary analysis for IgA, cystatin c and salivary flow rate.Material and method:This study performed in al- Yarmuk teaching hospital in Baghdad, Samples consist of (70)epileptics half of them treated with carbamazepine and other half treated with sodium valproate, and (18) healthycontrol group of both genders and with different ages to detect the prevalence of oral manifestations, salivary IgAand cystatin C changes.Results: Salivary IgA is significantly higher in epileptics than healthy group. DMFT is significantly lower in epileptics thanin healthy control. GI is hardly affected by epilepsy. Salivary flow rate was significantly lower in epileptics than thehealthy control group. On the other hand, cystatin C was obviously higher in epileptics but failed to reach the levelof statistical significance. Mucositis in epileptics was significantly higher. Candidal infection and Dysguisia failed toreach the level of statistical difference.Conclusion: The most affected oral measurement by epilepsy was salivary IgA then salivary flow rate followed byDMFT. Cystatin C had a marginal contribution to the context of case –control discrimination.Sodium valproate is saferthan carbamazepine when compared by its effects on the oral health. Mucositis, candida infection and dysguisiawere lower in epileptics who were treated with Sodium valproate. Salivary flow rate was higher in Sodium valproate -treated group than in carbamazepine group. GI and DMFT were lower in sodium valproate treated group than thecarbamazepine group

2%. الأورام الوراثیة والخلقیة والتنمویة، الصدمات النفسیة والتھابات الجھاز العصبي المركزي ھي من اھم اسباب الصرع. - الصرع اضطراب عصبي شائع معدل الاصابة 1ھدف دراسة: لتحدید مدى انتشار اضطراب التھاب الفم، وجفاف الفم، والذوق بین المرضى الذین یتناولون كاربامازبین أو الصودیوم فالبرویت وتحلیل امیونو غلوبیولین أ، سیستاتین جومعدل تدفق اللعاب .المواد والطریقة: ھذه الدراسة أجریت في مستشفى الیرموك في بغداد، تتكون العینات من ( 70 ) مریض مصاب بالصرع یتم علاج نصفھم مع كاربامازبین، والنصف الآخر معفالبرویت الصودیوم، وفریق مراقبة صحیة ( 18 ) من كلا الجنسین ومع الإعمار المختلفة للكشف عن انتشار التغییرات الشفویة، امیونو غلوبینالنتائج: امیونو غلوبیولین أ أعلى بكثیر في الصرع من مجموعة المراقبة. مقیاس التسوس أقل بكثیر في الصرع مما في مجموعة المراقبة. مقیاس التھاب اللثة لا یكاد یتأثر بالصرع.وكان معدل تدفق اللعاب أقل بكثیر في الصرع من مجموعة المراقبة الصحیة. في حین ان السیستاتین ج كان أعلى في الصرع ولكنھ فشل في الوصول إلى مستوى الدلالة الإحصائیة.التھاب الغشاء المخاطي في الصرع كان أعلى بكثیر. الإصابة بالفطریات وتغییرات التذوق فشلتا في التوصل إلى مستوى الفرق الإحصائي.الاستنتاج: المقساس الشفوي الأكثر تأثرا بالصرع كان الامیونوغلوبیولین أ ثم معدل تدفق اللعاب تلیھا مقیاس التسوس. وكان سیستاتین ج ذو مساھمة ھامشیة في سیاق التمییزبینالمصابین والاصحاء. فالبرویت الصودیوم أكثر أماناً من كاربامازبین إذا ما قورنت بإثارة على صحة الفم والأسنان. التھاب الغشاء المخاطي والفطریات واضطرابات التذوقكانتأقلفیالصرعالذینیتم علاجھمبفالبرویتالصودیوم. وكانمعدلتدفقاللعابأعلىفیمجموعة فالبرویتالصودیومممافیمجموعةكاربامازبین. مقیاس التھاب اللثھ ومقیاس التسوسكانتأقلفیمجموعةفالبرویتالصودیوم مما ھي علیھ في مجموعةالكاربامازبین


Article
Relation Between Salivary (Immunoglobulin A , Flow Rate and PH ) level and Estrogen Receptor Expression Among Patients with Breast Cancer
العلاقة بين المستوى اللعابي ل ( كلوبيولين المناعي أ، مستوى تدفق اللعاب , درجة الحموضة ) مع مستقبلات هرمونات الاستروجين في مرضى سرطان الثدي

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Abstract

Estrogen receptors (ERs) are a group of proteins , either of nuclear or membrane type , that activated by estrogen hormone which expressed in majority of breast cancer patients . Breast cancer is the most frequent cancer among the women and account about one third of the registered female malignancies. The relation between salivary immunoglobulin A (SIgA), Salivary Flow Rate (SFR) and PH of saliva with sex hormone receptors expression yet not well understood where there was few researches that highlights the nature of relation . The reduction in the SIgA and SFR often makes oral tissue more prone for infection. The objectives of this study is to determine the relation between the SIgA, SFR, PH, and sex hormone receptor expression in patients with breast cancer. study of cross sectional design was conducted from Jan. to Nov. 2016, samples of 3-5 ml of saliva collected from forty five (45) female patients with breast cancer at Oncology Teaching Hospital . The patients were categorized according to estrogen receptor status expression depending on their medical records (26 positive and 19 negative expression ). The sociodemographic characteristics and gynecological history including the age ,Body Mass Index(BMI), menopause status also reported. The SIgA, measured by Enzyme Linked Immunosorbent Assay technique (ELISA) , the SFR calculated by dividing the total collected saliva volume in milliliter by time in minute .The salivary PH measured by digital PH meter. Then the measured variables compared according to expression of estrogen receptor either positive or negative .The statistical analysis carried out by using independent student T- test and pearson correlation test were used to confirmed significant( p ≤ 0.05 ) was considered significant The results showed that the level of SIgA, SFR and salivary PH for group of ER+ ve expression were significantly lower than that of ER –ve expression where it was for ER+ve (136.8 , 155.7 and 5.8 ) while for ER-ve was (304.5, 248.5 and 6.1) respectively.also,the results revealed that a positive correlation between SIgA and SFR ( r=0.7) while a negative correlation between the SIgA and PH (r = -0.3) . We could conclude that the patients with breast cancer of ER+ve expression had low level of SIgA also had reduction in SFR which make them more prone for oral infection

مستقبلات الاستروجين هي مجموعة من البروتينات اما من النوع النووي او الغشائي والتي يتم تنشيطها عن طريق هرمون الاستروجين وتظهر في غالبية المصابين بسرطان الثدي . سرطان الثدي هو السرطان الأكثر شيوعا بين النساء ويمثل حوالي ثلث الأورام الخبيثة المسجلة للإناث وان العلاقة بين مستوى الكلوبيولين اللعاب المناعي نوع ا ، معدل و تدفق اللعاب و درجة حامضية اللعاب مع مستقبلات الهرمونات الجنسية (الاستروجين ) غير مفهومة جيدا حيث لم يكن هناك الكثير من البحوث التي تسلط الضوء على هذه العلاقة .وغاليا يؤدي الانخفاض في مستوى الكلوبيولين اللعابي المناعي أ وقلة تدفق اللعاب يجعل الانسجة الفموية اكثر عرضة للاصابة اهداف هذه الدراسة هي تحديد العلاقة بين مستوى الكلوبيولين المناعي أ , مستوى التدفق اللعابي ودرجة حموضة اللعاب مع مستقبلات الهرمون الجنسي ( استروجين ) لدى مرضى سرطان الثدي. اجريت الدراسة بتصميم الدراسة العرضية للفترة من شهر كانون الثاني ولغاية شهر تشرين الثاني ( 2016 ) ،( 3-5 ) مل من اللعاب تم جمعها من خمسة وأربعين (45) مريضة مصابة بسرطان الثدي في مستشفى الأورام التعليمي.و تم تقسيم المرضى باعتماد التعبير لمستقبلات هرمون الاستروجين التي تم توثيقها في سجلاتهم الطبية الى مجموعتين شملت الاولى مجموعة المرضى الايجابية التعبير لمستقبلات الاستروجين (26 ) مريضا و المجموعة الثانية شملت 19 مريضا بتعبير سلبي للاستروجين . وتم تسجيل معلومات المريض المتعلقة بالخصائص الاجتماعية والديموغرافية وتاريخ الأمراض النسائية والعمر ، مؤشر كتلة الجسم و تاريخ سن اليأس. اما المستوى اللعابي للاميونوكلوبيولين أ تم قياسه بواسطة تقنية فحص الامتصاص المناعي المرتبط بالإنزيم (ELISA) ، وتم حساب مستوى تدفق اللعاب عن طريق قسمة إجمالي حجم اللعاب المجمع في المليلتر في الدقيقة . وتم قياس درجة حموضة اللعاب بواسطة مقياس الحموضة الرقمي. ثم قارنت مستويات المتغيرات المقاسة وفقاً للتعبير عن مستقبلات هرمون الاستروجين سواء كانت موجبة أو سالبة و تم استخدام التحليل الإحصائي باستخدام اختبار T-test واختبار ارتباط Pearson واعتمد قيمة (p ≤ 0.05) لتاكيد الاختلاف.اظهرت النتائج أن مستوى الغلوبيولين المناعي أ و مستوى تدفق اللعاب ودرجة حموضة اللعاب في المجموعة الموجبة لمستقبلات الاستروجين ( 136.8, 0.7 , 5.8 ) غلى التوالي كانت أقل من مستوياتها في المجموعة السالبة لمستقبلات الاستروجين وبفرق معنوي (304.5 و 1.4 , 6.1) على التوالي.كذلك اكدت الدراسة بوجود علاقة طردية بين مستوى الاممينوكلوبيولين أ ومستوى تدفق اللعاب بمعامل ارتباط7 r=0. وعلاقة عكسية بين مستوى المينوكلوبيولين وحموضة اللعاب بمعامل ارتباط r= -0.3 نستنتج أن المرضى الذين يعانون من سرطان الثدي من مجموعة الموجبة لمستقبلات الاستروجين لديهم مستوى منخفض من امينوكلوبيولين أ اللعابي و قلة في مستوى تدفق اللعاب مما يجعلهام أكثر عرضة للامراض الفموية .

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