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Study of the effect of hyperthyroidism on the serum cholesterol and albumin level in women in Najaf
دراسة تأثير زيادة إفراز الغدة الدرقية على مستوى الكولسترول والألبومين في مصل النساء في محافظة النجف

Author: Sheymaa G. shamran Al-jafery
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2012 Volume: 2 Issue: 2 Pages: 142-146
Publisher: University of Kufa جامعة الكوفة

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Abstract

Abstract:Objectives: to study the impact of increased thyroid secretion on levels of serum cholesterol and albumin in serum women.Methodology: a study in applied AL-Sader educational hospital for the period from March 2011 to August 2011 including the study the measuring of concentration of cholesterol and albumin in serum blood of (53) women patients of hyperthyroidism. The researcher used statistical analysis of data.Results: the search results showed significant decrease in the rate of albumin concentration compared to control group (p < 0.001). And a decrease in cholesterol concentration compared with the control group (p < 0.001).Recommendations: the study recommends compensation decrease blood cholesterol and with increased thyroid secretion by addressing the complementary and healthy food appropriate for each situation.

الخلاصة:الأهداف : لمعرفة تأثير زيادة إفراز الغدة الدرقية على مستويات الكولسترول والألبومين في مصل النساء.منهجية البحث : أجريت دراسة تطبيقية في مستشفى الصدر التعليمي للفترة من آذار 2011 إلى آب 2011 حيث شملت الدراسة قياس تركيز الألبومين والكولسترول في مصل دم(53) من النساء المريضات بمرض فرط الغدة الدرقية. واستخدم الباحث التحليل الإحصائي للبيانات المأخوذة.النتائج :أظهرت نتائج البحث نقصان معنوي في معدل ألألبومين مقارنة مع مجموعة السيطرة (p<0.001). ونقصان معنوي في معدل الكولسترول مقارنة مع مجموعة السيطرة(p<0.001) .التوصيات : توصي الدراسة بتعويض نقصان الألبومين والكولسترول في الدم ممن لديهم زيادة إفراز الغدة الدرقية بتناول المتممات الغذائية والغذاء الصحي المناسب لكل حالة.


Article
Study of the effect of hypothyroidism on the serum cholesterol and albumin level in women in Najaf.
دراسة تأثير نقصان إفراز الغدة الدرقية على مستوى الكولسترول والألبومين في مصل النساء في محافظة النجف

Author: Sheymaa G. shamran Al-jafery
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2014 Volume: 4 Issue: 2 Pages: 183-187
Publisher: University of Kufa جامعة الكوفة

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Abstract

Objectives: to study the impact of decreased thyroid secretion on level of serum cholesterol and albumin in serum women.Methodology: a study in applied AL-sader educational hospital for the period from April 2013 to August 2013 including the study the measuring of concentration of cholesterol and albumin in serum blood of (65) women patient of hypothyroidism .the researcher of used statistical analysis of data.Results: the search results showed significant increased in the rate of cholesterol compared to control group (p<0.05) and non-significant in the rate of albumin compared to control group (p<0.05). Recommendation: the study recommends to decreased the high rate of cholesterol with patient of hypothyroidism by taking thyroxin to erect the thyroid gland to normal action. Conclusion: thyroid hormones regulated serum cholesterol and albumin. The decreased serum thyroxin is attributable to the presence of an abnormal human serum cholesterol.

الهدف :لمعرفة تأثير نقصان إفراز الغدة الدرقية على مستوى الكولسترول وألالبومين في مصل النساء.المنهجية:أجريت دراسة تطبيقية في مستشفى الصدر التعليمي للفترة من نيسان 2013 إلى أب 2013 حيث شملت الدراسة قياس تركيز الألبومين والكولسترول في مصل دم (65) من النساء المريضات بمرض نقصان إفراز الغدة الدرقية. واستخدم الباحث التحليل الإحصائي للبيانات المأخوذة.النتائج:أظهرت نتائج البحث زيادة معنوية في معدل الكولسترول مقارنة مع مجموعة السيطرة (P<0.05 ) ولم تظهر أي فرق معنوي في معدل الألبومين مع مجموعة السيطرة P<0.05) ).الاستنتاجات:هرمونات الغدة الدرقية تؤثر على معدل الكولسترول والألبومين حيث ان نقصان الثايروكسين يؤدي الى تغيير معدل الكولسترول في الانسان.التوصيات:توصي الدراسة بتقليل نسبة الكولسترول في الدم ممن لديهم نقص إفراز الغدة الدرقية بواسطة استخدام الثايروكسين للمرضى بنقص إفراز الغدة الدرقية لإرجاع الغدة الدرقية للعمل بشكل طبيعي.


Article
Levels of Zinc & Copper in Acute Pancreatitis Patients

Author: Sundus Khawam. Al-Khazraji
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 3 Pages: 203-205
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Acute pancreatitis has traditionally been defined as an acute inflammatory process of the pancreas that (1) is associated with abdominal pain and elevations in serum levels of pancreatic enzymes and, (2) disrupts normal pancreatic architecture and function.AIM OF THE STUDY:To assess the serum level of zinc and copper in patients with acute pancreatitis.METHOD:A study conducted in Gastrointestinal Teaching Hospital in Baghdad, from first May 2005 to first March 2006, twelve patients were eligible in this study, and they were 4 females & 8 males. Zinc & Copper were measured for every patient by Perkin-Elmer (USA) atomic absorption spectrophotometer model 305B fitted with nitrous oxide acetylene burner head.RESULTS:Zinc & Copper concentrations were significantly decreased (p <0.001 and p<0.0001 respectively) in the serum of acute pancreatitc patients.CONCLUSION:These findings of Zinc & Copper levels suggest that altered minerals metabolism in serum may have contributed to the pathophysiology of acute pancreaitits

Keywords

Acute pancreatitis --- Zinc --- Copper --- Serum level


Article
NEUTROPHIL ACTIVATION THROUGH THE EXPRESSION OF CD11a, CD11b AND CD11c AND ITS ROLE WITH COMPLEMENT C3 AND C4 LEVELS IN PATIENTS WITH PRE-ECLAMPCIA

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BackgroundThe leukocyte integrin that plays a major role in neutrophil activities is CD11b. In addition to mediating neutrophil adherence to endothelial cells, CD11b binds to the complement component iC3b and directs phagocytosis and intracellular lysis of microorganisms.ObjectiveTo determine whether neutrophil activation, through the increased surface expression of the cell surface markers CD11a, CD11b, CD11c have a correlation with the values of complement components C3 and C4 in pregnant women with pre-eclampsia.MethodsThis study was conducted at the AlKadhemiya Teaching Hospital. Patients were 60 pregnant women in labour subdivided into three groups:Group A: 20 pregnant women with severe pre-eclampsia.Group B: 20 pregnant women with mild-moderate pre-eclampsia.Group C: 20 normotensive pregnant women (control group).We performed the following laboratory measurements for all groups: total white blood cell WBC count, cell surface expression of CD11a, CD11b, CD11c by direct immunofluorescent technique, and serum complement C3 and C4 levels by radioimmunodiffusion method (RID).ResultsThere was a significant difference in neutrophil activation as detected by the cell surface expression of CD11a, CD11b, CD11c being higher in the pre-eclamptic group than the control group. The incidence of neutrophil activation was significantly higher among patients in group A compared to the other groups. There was a significant difference in the serum level of C3 and C4 in the pre-eclamptic group being higher in group A and B than group C.ConclusionsNo correlation was found between the markers of neutrophil activation (CD11a, CD11b, CD11c) and the serum levels of (C3, C4) in the pre-eclamptic group. The incidence of adverse maternal and neonatal outcome is significantly higher among patients in group A compared to the other two groups.Key wordsPreeclampsia, complement serum level, CD11a, CD11b, CD11C, neutrophil.


Article
Serum heavy metals in patients with fragments and shells of improvised explosive devices

Authors: Mowafak K. Hassan موفق حسن --- Nabeel H. Alfhady نبيل حمد الله --- Mahmood A. Aljumaily محمود عبد الجميلي
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2011 Volume: 37 Issue: 1&2 Pages: 8-13
Publisher: Mosul University جامعة الموصل

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Abstract

Background: Iraq is the most affected country by injuries of improvised explosive devices (IED) including bomb car, bomb born on person and roadside bombs. Embedded fragments and shells can release heavy metal. High level of heavy metal in serum carries dangerous long term risk for injured patients.Objective: The aim of this study is to estimate the serum level of heavy metals (copper, lead, cadmium, nickel, and zinc) in patients with fragments and shells from IED including bomb car, bomb born on person and roadside bombs. Material and methods: Serum concentrations of heavy metals (copper, lead, cadmium, nickel, and zinc) were assayed using atomic absorption spectrophotometry in 52 patients with fragments and shells from IED. Serum concentrations of heavy metals were measured in 52 healthy adults as control group. Results: The mean serum level of copper, lead, cadmium, nickel, and zinc in patients were 1304 ± 258.1 µg/L, 36.5 ± 16.7 µg/L, 6.203 ± 2.372 µg/L, 0.387 ± 0.183 µg/L, and 1651 ± 532 µg/L respectively, while in control were 824.2 ± 203.6 µg/L, 31 ± 15.1 µg/L, 1.654 ± 0.4 µg/L, 0.239 ± 0.028 µg/L, 619 ± 234 µg/L respectively. The differences in serum copper, lead, cadmium, nickel, and zinc between patient and control is highly significant, (P value < 0.0001), while the differences in serum lead between patient and control is not significant ( P value > 0.05).Conclusion: The present study demonstrates that a highly significant increase in serum level of copper, cadmium, nickel, and zinc in patient with fragments and shells from IED in comparison with control group, while the difference in serum lead in patients and control was not significant. Keywords: Improvised explosive devices, fragment, shell, metal, serum level.

الخلفية: العراق هو البلد الأكثر تأثرا بإنفجارات السيارات المفخخة والعبوات والأحزمة الناسفة وان الشظايا الداخلة في أجسام المرضى من الممكن إن تحرر معادن ثقيلة داخل الدم وان ارتفاع مستوى المعادن الثقيلة في الدم يعد خطر جدا في المرضى المصابين. الأهداف: إن هدف الدراسة هو تحديد مستوى المعادن الثقيلة (النحاس، الرصاص، الكادميوم، النيكل والزنك) في دم المرضى المصابين بشظايا إنفجارات السيارات المفخخة والعبوات والأحزمة الناسفة.المواد وطريقة العمل: تم قياس مستوى المعادن الثقيلة (النحاس، الرصاص، الكادميوم، النيكل والزنك) بواسطة جهاز امتصاص الطيف الضوئي الذري في دم 52 مريضا من المصابين بشظايا إنفجارات السيارات المفخخة والعبوات والأحزمة الناسفة. وتم قياس نفس المعادن وبذات الطريقة في دم 52 شخصا من الأصحاء كمجموعة ضابطة. النتائج: كان معدل مستوى النحاس، الرصاص، الكادميوم، النيكل والزنك على التوالي في دم المرضى 1304 مايكرو غرام /لتر، 36,5 مايكرو غرام/لتر، 6,2 مايكرو غرام/لتر، 0,387 مايكرو غرام/لتر، 1651 مايكرو غرام/لتر. أما في المجموعة الضابطة فكانت 824,2 مايكرو غرام/لتر، 31 مايكرو غرام/لتر، 0,165 مايكرو غرام/لتر، 2,396 مايكرو غرام/لتر، 619 مايكرو غرام/لتر ويعد الفرق معنوي بالنسبة لكل من مستوى النحاس، الكادميوم، النيكل والزنك وغير معنوي بالنسبة للرصاص. الاستنتاج: كان هناك ارتفاعا في مستوى المعادن الثقيلة وكان الفرق معنويا عند المرضى المصابين بالشظايا في مستوى النحاس والكادميوم والنيكل والزنك عند المقارنة مع المجموعة الضابطة ولم يظهر مستوى الرصاص فرقا معنويا.


Article
Study of Serum Level of Interleukin 2
Interleukin 10

Author: Interleukin 10
Journal: journal of the college of basic education مجلة كلية التربية الاساسية ISSN: 18157467(print) 27068536(online) Year: 2015 Volume: 21 Issue: 90 / علمي Pages: 69-77
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Article
Serum Level of TNF-α and IL-17 in Patient Have Chronic Periodontitis Associated Rheumatoid Arthritis

Authors: Munir Nasr Hamed, منير نصر حامد --- Basima Gh. Ali
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2017 Volume: 29 Issue: 1 Pages: 104-110
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: chronic periodontitis and rheumatoid arthritis are widely prevalent diseases and are characterized by tissue destruction due to chronic inflammation. Recently, there is growing evidence that the two diseases share many pathological features the aims of the study To determine the periodontal health status in patient have chronic periodontitis with rheumatoid arthritis and compare it with those having chronic periodontitis without Rheumatoid arthritis and determine the serum levels of interleukin -17(IL-17), tumor necrosis factor- alpha (TNF-α ) in both groups and compare with the control group (subject samples neither have periodontitis nor arthritis ) and correlate these immunological markers with the periodontal parameters Plaque index , gingival index , bleeding on probing, probing depth, clinical attachment level and number of missing teeth.Materials and methods: Eighty (80) males and females subjects with age range (30-45) years were recruited in this study they were divided into three main groups The chronic periodontitis with rheumatoid arthritis group consist of thirty (30) subjects and second group consist of thirty (30) subjects have chronic periodontitis and third group consist of twenty (20) subject case control group. All subjects had normal weight and height range according to BMI (body mass index) that it value is (18.5-25), Clinical periodontal parameters used in this study were Plaque index, gingival index, bleeding on probing, clinical attachment level index, probing pocket depth and number of missing teeth was measured in all groups at four surfaces of all presented teeth Blood samples were collected from all individuals and examined to determined serum level of interleukin -17 and tumor necrosis factor-a by mean of enzyme-linked immune–sorbent assay.Results: The present study showed patients with chronic periodontitis and rheumatoid arthritis had higher prevalence of sites presenting dental plaque, a higher rate of gingival inflammation and bleeding on probing greater probing depth, greater attachment loss and high number of missing teeth compared to those had chronic periodontitis only and control subjects . Also highly significant differences between studied group regarding serum level of IL-17 and TNF-α atp < 0.001, as well as, it revealed that mean serum levels of IL-17 were statistically higher in chronic periodontitis with rheumatoid arthritis group (607.9 ± 79.9) than Chronic Periodontitis group (421.4 ± 5.9) and Control groups (15.9 ± 2.7) similarly serum level of TNF-α (402.2 ± 41.2 319.4 ± 526 85.3 ± 4.9) respectively at p < 0.001. Regarding correlation, the current study observed strong positive correlation between serum levels of IL-17 andTNF-α with PL.I, GI, BOP, PPD CAL and the number of missing teeth in the PRA at p<0.001. Also this study reveal significant correlation between the two immunological markers (TNF-α and IL-17) in chronic periodontitis with rheumatoid arthritis group and in Chronic Periodontitis group.Conclusion: It was concluded that there was higher potentiality to chronic periodontitis involvement among rheumatoid arthritis patients, that correlated positively with increase the level of serum levels of IL-17 and TNF-α accordingly with high score of clinical parameters that had recorded. That mean TNF –a and IL-17 may play an important role in increase the severity of periodontitis as well as rheumatoid arthritis


Article
The Significance of Maternal total Serum Homocysteine level in Iraqi Mothers who had previous Babies with Neural Tibe Defects

Authors: Salma A. AL-Taha بسام موسى صادق --- Bassam M. Sadik
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2006 Volume: 48 Issue: 3 Pages: 323-325
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Neural tube defects (NTDs) are said to be inherited in a multifactorial fashion, i.e. genetic-environmental interaction. Maternal nutritional deficiencies had long been reported to cause NTDs, especially folate deficiency during early pregnancy. More attention had been paid to the exact mechanism by which this deficiency state causes these defects in the developing embryo. The most significant of all researches was that connecting reduced folate and increased homocysteine level in maternal serum on one hand and the risk of developing a NTD baby on the other hand.Objectives : to determine the significance of homocysteine level in Iraqi mothers who gave birth to babies with NTDs as compared to normal controls.Patients, Materials and Methods: Fifty Iraqi women having babies born with NTDS, referred to the genetic clinic in Baghdad Teaching Hospital, were included in this study (the study group) as well as 37 healthy women having normal children (the control group). This study was conducted from November, 2002 till October, 2003. Analysis of total serum homocysteine level for all women was done using a computerized HPLC system.Results : the age of women in both groups was comparable (mean+SD in the study group was 26.2+5.14 years vs. 26.3+4.57 years in the controls). Among the study group, 4 (8%) had normal tHcy level; 44 (88%) had mildly elevated level, and only 2 (4%) had moderately elevated tHcy level, while all (100%) women in the control group had their tHcy level within normal level. This difference was statistically highly significant (p<0.001).Conclusions : Women become at an increased risk of delivering a baby with NTD when having an elevated tHcy level in their sera, and that tHcy level is an important marker in maternal serum that is associated significantly with pregnancy outcome.


Article
Measurement of Adenosine Deaminase Concentration in Serum of Breast Cancer by HPLC before and after Chemotherapy in Hilla City

Authors: Ali Mohammed Jawad --- Mufeed Jalil Ewadh --- Alaa Sadiq Al awad
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 661-669
Publisher: Babylon University جامعة بابل

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Abstract

Breast cancer (BC) is a type of malignancy appeared in breast tissue , occurs in both premenopausal and also in postmenopausal women's. Adenosine deaminase (ADA) is an enzyme participate in metabolism of purine. However, the level of adenosine deaminase increased in most cancers patients and it could be of value before and after chemotherapy. A total of 280 patient with (BC) divided in two groups, first group (n=40) women with breast cancer without chemotherapy, second group (n= 240 ) women with breast cancer with chemotherapy, this group was divided into six groups according to the doses used (1st – 6th doses). The control group (n= 40) apparently healthy women's matched with patient group. Women with (BC) have a significant higher serum level of ADA than those who are not diseased (p<0.001) and even than those who received chemotherapy (p<0.05 ).So, this lead to a conclusion that; breast cancer women have higher level of ADA . ADA level decreased upon administration of chemotherapy. The objective of this study is to assess ADA status in women's BC receiving chemotherapy treatment.


Article
Study of Serum Level of Interleukin 2, Interleukin 10 and Tumor necrosis factor-α in sample of Iraqi psoriasis patients

Author: ss. Prof. Dr. Talib Abdulla Hussein Azhar Jassim Mohsen Hind yousif khalaf
Journal: journal of the college of basic education مجلة كلية التربية الاساسية ISSN: 18157467(print) 27068536(online) Year: 2016 Volume: 21 Issue: 91/علمي Pages: 1-12
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract :The aim of this study was to determine the Th1 and Th2 serum cytokines, in patients with psoriasis and to compare their cytokine levels with those of normal control subjects. where study included 55 Iraqi patients with psoriasis:30 (15 females ,15 males) were untreated with any drugs. The other patient group consist of 25 (9 female and 16 male) treated with a biological treatment (infliximab) ,and 30 healthy control group were withdrawn (5) ml of venous blood for both patients and members of the control ,to conduct Immunological tests to determine the quantitative for each of level of IL-2,IL-10 and TNF-α in a manner (ELISA). The results showed significant increase in the level of probability (P <0.05) in the rate of level of IL-10 and TNF-α in patients compared to the control (healthy) .As well as the result also show no significant increases of IL-2.From this we can deduce that pro inflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of psoriasis, the increase of IL-10 and TNF-α indicated the balance between the proinflammatory and the anti-inflammatory cytokine .

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