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Article
The Chages in Sex Hormones in Female Working in Battries Manufacturing Plant

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Abstract

Lead has toxic effects on reproduction of both male and female. It can cause decreased sex drive , infertility and abnormal menstrual cycle in women. This study was designed to evaluate the effect of exposure to lead in batteries female workers on sex hormones level in the serum.Thirty nine (39) female workers (volunteers) in Iraqi Batteries Manufacturing Plants, Al-Waziriya / Baghdad were participated in this study. They are classified into 3 groups, first group included fourteen (14) female that have been employed for 1-7 years , second group included thirteen (13) female that have been employed for 8-14 years , third group included twelve (12) female have been employed for15-22 years and and fourteen females were included as the control . Blood lead level, serum FSH, LH, prolactin and total testosterone were measured and compared for all subjects.The results indicated that mean of blood lead levels (BLL), testosterone levels were highly significant in all worker groups compared to the control (p<0.005).Prolactin levels in group I and FSH in group III were significantly higher than that in control ( P< 0.005) and (P<0.05) respectively. LH levels in groups II and III were significantly higher than that in control (P<0.05, P<0.005 respectively). High incidence of hirsutism (48%) and miscarriages (50%) were observed in worker groups compared to control (11%). The results indicated that there are hormonal changes in female workers exposed to lead associated with increased incidence of hirsutism and miscarriages compared to non exposed females .

تسعة وثلاثون امرأة عاملة في معمل صناعة البطاريات في بغداد شاركن في هذه الدراسة كمتطوعات قسمت العاملات الى ثلاث مجاميع اعتمادا على فترة التعرض للرصاص.١-المجموعة الأولى تشمل (١٤) عاملة وفترة الخدمة تتراوح بين (١ـ٧) سنوات وبعمر (٢٤ـ٥٠) سنة.٢ـ المجموعة الثانية تشمل (١٣) عاملة وفترة الخدمة تتراوح بين (٨ـ١٤) سنة وبعمر (٣٠ـ٥٥) سنة ٣ـ المجموعة الثتلثة تشمل (١٢) عاملة وفترة الخدمة تتراوح بين (١٥ـ٢٢) سنة وبعمر (٣٢ـ٥٢) سنة.٤-المجموعة الرابعة: مجموعة السيطرة وتشمل (١٤) امرأة بمتوسط عمر( ٢٩±١.٧) سنة.وجد في هذه الدراسة ان هنالك تغير في مستوى الهرمونات الجنسية عند النساء العاملات عند مقارنتها بمجموعة السيطرة.وجد كذلك ان مستوى الهورمون اللوتيني في المصل يزداد عند العاملات اللواتي تعرضن للرصاص لفترة طويلة اما هورمون محفز الجريب في المصل يزداد فقط عند النعرض لفترة طويلة.اما هورمون (البرولاكتين ) فيزداد فقط بعد التعرض لفترة قصيرة للرصاص.كذلك هورمون التيستوستيرون الكلي يزداد عند النساء العاملات متصاحبا مع زيادة في نسبة الشعرانية والاسقاطات عند العاملات مقارنة بمجموعة السيطرة.


Article
DIGITAL DERMATOGLYPHIC CHARACTERISTICS IN PATIENTS WITH SEX HORMONES ANOMALIES

Authors: Rakad M. Kh. Al-Jumaily --- Fadhel M. Lafta --- Lamees Kh.I. Al-Dahiri --- Laith Z.Fadhil
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2010 Volume: 13 Issue: 2 Pages: 164-169
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background : Dermatoglyphics are the dermal ridge configurations on digits ,palms and soles.Dermatoglyphic polymorphism results from the interaction of genetic and environmental factors.The dermatoglyphic analysis is a valuable completion of initial diagnosis of some syndromes anddiseases that are genetically determined. Our objective was to assess the relationship betweendigital dermatoglyphic patterns and sex hormones anomalies.Methods : Dermatoglyphic pattern type frequencies (qualitative analysis ), total and absolute ridgecounts (quantitative analysis )and left /right asymmetry were assessed for 54 males with sexhormones anomalies and 55 controls .Results : Dermatoglyphics pattern type frequencies were altered in patients with sexhormones anomalies versus controls . In particular, there was an increase and decrease of whorls(38.2% vs. 33.5%) and ulnar loops (51.7% vs. 58.5%) respectively. The differences weresignificant ( χ2 = 10.335 ; D.F. = 3 ; P ≤0.05 ) .In quantitative analysis , patients showeda higher mean ridges count than controls in both; the TRC (159.81 } 5.46 vs. 144.61 } 5.84 ) andARC (213.72 } 11.19 vs. 187.96 } 11.07 ) respectively ,and a significant difference was observedin TRC analysis (t = 1.899 ; d.f. = 107 ; p = 0.06 ). Among patients with sex hormones anomalies44.44% of them had a higher ridge counts on the left hand than on right hand versus 38% incontrols .Conclusion: Our results supported the hypothesis that prenatal sex hormones levels may have asignificant effect on the development of dermatoglyphics.

الخلفية العلمية : يعنى علم الخطوط الجلدية بدراسة أشكالالخطوط الجلدية في البنان ، راحة الكف وباطن القدم .و إنتعدد أشكال الخطوط الجلدية هو نتاج لتظافر عوامل الوراثةوالبيئة . كما أن تحليل صفات الخطوط الجلدية قد أصبح ذوقيمة في التشخيص الأولي لبعض المتلازمات والأمراضالوراثية .وقد هدف بحثنا إلى تقييم العلاقة بين أنماطالخطوط الجلدية للبنان واضطراب الهورمونات الجنسية .العمل: تم حساب تكرار أنماط الخطوط الجلدية ( التحليلالوصفي ) ، وعدد الخطوط الجلدية الكلي والمطلق( التحليل الكمي ) وعدم التناظر لعدد الخطوط ل 54 ذكراًيعانون من اضطراب الهورمونات الجنسية و 55 فرداًيمثلون مجموعة السيطرة .النتائج : اظهر مرضى اضطراب الهورمونات الجنسيةاختلافا في تكرار انماط الخطوط الجلدية مقارنة بمجموعةالسيطرة ، وخاصة زيادة المستديرات ( 38.2 % مقابل%33.5 ) ونقصان العرويات الزندية ( 51.7 % مقابل%58.5 ) ، وقد وصل الاختلاف الى المتسوى المعنوي: (قيمة مربع كاي = 10.335 : درجة الحرية = 3. ( الاحتمالية 0.05أما بالنسبة للتحليل الكمي فقد اظهر المرضى زيادة فيمعدل عدد الخطوط الجلدية مقارنة بمجموعة السيطرة ،5.46 مقابل ± بالنسبة لمعدل عدد الخطوط الكلي ( 159.815.84 ± 144.61 ) وكذلك لمعدل عدد الخطوط المطلق11.07 ). وكان ± 11.19 ± 213.72 مقابل 187.96 )الاختلاف معنوياً بالنسبة لمعدل العدد الكلي للخطوطكما ظهر بأن . (t = 1.899 ; d.f. = 107 ;p = 0.06)%44.44 من المرضى يحملون عدداً اكبر من الخطوط فياليد اليسرى مقابل 38 % من مجموعة السيطرة .الاستنتاج : نتائج بحثنا تدعم الافتراض العلمي بأنمستويات الهورمونات قبل الولادة تمتلك تأثيراً معنوياً علىتكوين الخطوط الجلدية .


Article
Study the Effect of Sex Hormones in Diabetic Women

Author: Aufaira shaker nsaif عفيرة شاكر نصيف
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2014 Volume: 27 Issue: 1 Pages: 18-20
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Objectives: The purpose of our study was to investigate the association of C-peptide and steroid hormones (progesterone and testosterone) and type 2 diabetes in diabetic women under 42 years age.Materials and Methods: Thirty, type 2 diabetic women under 42 years old (35-42) years and 30 non diabetic women as control were investigated in this study, age and sex matched. Sex hormones (progesterone and testosterone) were measured by using minividas (Biomerieux). Also serum C-peptide was measured by using gamma counter (Wallac) and fasting blood sugar by using spectrophotometer. All measurements were done in the National Diabetes Center (NDC) / Al-Mustansiriya University, Baghdad - Iraq.Results: the progesterone, testosterone, FBS and C-peptide of diabetic women were 2.963±1.29 pmol/l, 0.150±300 pmol/l, 132.53±9.69 mg/l and 4.25±1.16 ng/l respectively; while the control healthy women were 2.865±0.988 pmol/l, 0.295±0.196 pmol/l, 87.45±7.53 mg/l and 3.76±0.49 ng/l respectively. Differences between diabetic and control women for the testosterone, FBS and C-peptide were statistically significant and for the progesterone were statistically insignificant. Conclusion: There is a strong association between the sex hormones and type 2 diabetes mellitus. Key words: sex hormones, diabetes

Keywords

sex hormones --- diabetes


Article
Effect of sex hormones level on the external genital tract infection in pregnant and non- pregnant women in Dhi Qar governorate, Iraq

Authors: Safa Abdul wehab wajeh صفا عبد الوهاب وجيه --- Basim Abdul Hussein باسم عبد الحسين --- Mohanad Abdul Razzaq مهند عبد الرزاق
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2018 Volume: 6 Issue: 4 Pages: 9-17
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

The current study was conducted in Dhi Qar governorate, Iraq to determine the main types of microorganisms that cause female genital tract infection and the extent of the effect of the level of sex hormones (prolactin, progesterone, estrogen) on the presence of infection , 245 samples were collected for both vaginal swabs and blood (where take a vaginal swab and blood from every woman) , where 150 women were pregnant and 95 women non-pregnant women , aged 16-45 years . Among non-pregnant women, most were women who had a reproductive tract infection within the leuteal phases , where our study included 58 women at leuteal phase , 20 women were in follicular phase , 17 women within ovulation phase of the menstrual cycle .The study showed that Candida albicans , Staphylococcus aureus , Escherichia coli , Gardnerella vaginalis , Klebsiella pneumonia , Staphylococcus epidermids , Enterobacter cloaceae were isolated from women in follicular phase , the diversity of infections was lower in women in the ovulation stage, where they were isolated only Candida albicans , Staphylococcus aureus , Escherichia coli , Gardnerella vaginalis ,and from women with leuteal phase was obtained Candida albicans , Staphylococcus aureus , Escherichia col ,Gardnerella vaginalis , Klebsiella pneumonia , Staphylococcus epidermids , Proteus mirabilis, Pseudomonas aeruginosa , the precence of all type of pathogens in our study was associated with elevated estrogen and progesterone levels except the growth of Staphylococcus epidermids , Proteus mirabilis, Pseudomonas aeruginosa , Enterobacter cloaceae was associated with normal range of each hormones,as for the prolactin hormone did not have a clear effect as the levels ranged between natural and high for all women in the three phases. Pregnancy was accompanied by high levels of estrogen, progesterone and prolactin hormones, this is accompanied with existence Candida albicans , Staphylococcus aureus , Escherichia coli , Gardnerella vaginalis , Klebsiella pneumonia , Streptococcus agalactiae , Trichomonas vaginalis.


Article
Ameliorative Effect of Fenugreek on sex hormones in Polycystic Ovary Syndrome Female Rats Induced by Letrozole
التأثير المحسن للحلبة على الهرمونات الجنسية في إناث الجرذان المستحدث فيها متلازمة تكيس المبايض المتعدد بوساطة اليتروزول

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The present study was carried out in the animal house of the College of Veterinary Medicine/ University of Basrah to investigate the role of the treatment with metformin (Met), ethanolic extract of fenugreek (FN) each alone and their combination on the sex hormones changes in polycystic ovary syndrome induced in female rats. For this purpose, the study included two experiment. First experiment aimed to determine the changes in the hormones concentration of pituitary ovarian axis associated with PCOS, induced by letrozole in rats. Fifty six adult female rats randomly divided in to two group, first group (n=16) administrated 0.5% carboxy Methyl Cellulose (CMC) 0.2ml/rat/orally by gavage and served as control group and second group (n=40) administered Letrozole (1mg/kg B.W/day) dissolved in 1ml of 0.5% carboxymethylcellulose (CMC) orally by gavage for 21 days to induced PCOS. Vaginal smear examination of all female rats was done to ensure the occurrence of PCOS. At the end of the experiment eight rats of each group were sacrificed. Blood samples were collected and serum were separated for hormonal assay. The results revealed a significant increase in serum concentration of luteinizing hormone (LH) and testosterone (T) in PCOS group compared with control group. On other hand a significant decrease in serum concentration of estrogen (E2), and progesterone (P4) in PCOS group compared with control.Second experiment: This experiment was designed to evaluate the role of metformin, fenugreek and their combination therapy in amelioration effect of sex hormones changes of induced PCOS in female rats. The remainder animals from 1st experiment (8 rats from control group and 32 rats from PCOS group) were divided into five equal subgroups including eight rats in each group as follows, First group (Negative control): Rats from the control group of first experiment were administrated of 0.2 ml/rat distilled water (D.W) / daily by oral gavage. Second group (PCOS): PCOS-induced rats administrated 0.2ml/rat D.W daily by oral gavage. Third group (PCOS+Met): PCOS-induced rats were administrated 50mg/kg B.W Met daily by oral gavage. Fourth group,(PCOS+FN): PCOS-induced rats were administrated 15mg/kg B.W FN daily by oral gavage. Fifth group (PCOS+Met+FN): PCOS-induced rats were administrated both Met and FN (50mg and 15 mg)/kg B.W respectively daily by oral gavage. The treatments were extended for 21 days.. Blood samples were collected and serum were separated for hormonal assay. The results revealed that serum concentration of LH and T still significantly higher and serum concentrations of E2 and P4 significantly lower in -Ve PCOS group compared with control after 21 days of treatment. A significant degrees of improvement were recorded in above cited parameters in all treatment groups compared with -Ve PCOS and control groups.

أجريت الدراسة الحالية في البيت الحيواني لكلية الطب البيطري / جامعة البصرة للتحري في دور العلاج بالميتفورمين (Met) والمستخلص الإيثانولي للحلبة (FN) كل بمفرده وكلاهما معا على التغيرات بتركيز الهرمونات الجنسية في متلازمة تكيس المبايض المتعدد المستحدثة في إناث الجرذان. لهذا الغرض، شملت الدراسة تجربتين.التجربة الأولى: هدفت هذه التجربة للتعرف على بعض التغيرات الكيموحيوية والنسجية المرتبطة بمتلازمة تكيس المبايض المستحدثة بوساطة اليتروزول في إناث الجرذان. استخدم في هذه الدراسة ستة وخمسين من إناث الجرذان البالغة قسمت عشوائيا إلى مجموعتين، المجموعة الأولى (n=16) أعطيت كربوكسي ميثيل السليلوز (CMC)0.2 ml /جرذ بتركيز 0.5% عن طريق الفم واعدت مجموعة سيطرة والمجموعة الثانية ( n=40) أعطيت ليتروزول (1mg/kg B.W/day) مذاب في 1ml من 0.5%كاربوكسي ميثيل السيلولوز (CMC) عن طريق الفم. استمرت المعاملة لمدة 21 يوما لاستحداث متلازمة تكيس المبايض. تم إجراء فحص لمسحات من المهبل لجميع إناث الجرذان خلال هذه الفترة للتأكد من حدوث متلازمة تكيس المبايض. في نهاية التجربة تم التضحية ب ثمانية جرذان من كل مجموعة. جمعت عينات الدم وتم فصل مصل الدم لقياس مستوى الهرمونات. وقد أظهرت النتائج ما يلي:. أظهرت النتائج وجود زيادة معنوية في تركيز مصل الهرمون اللوتيني (LH) وهرمون الشحمون الخصوي (T) في مجموعة تكيس المبايض مقارنة مع مجموعة السيطرة. من ناحية أخرى لوحظ انخفاض معنوي بتركيز هرمون الاستروجين (E2)، والبروجسترون (P4) في مجموعة تكيس المبايض مقارنة مع السيطرة.التجربة الثانية: تم تصميم هذه التجربة لتقييم دور الميتفورمين (Met) والمستخلص الكحولي للحلبة (FN) كل لوحده أوكلاهما في تحسين التغيرات في تركيز مستوى الهرمونات الجنسية الناتجة من متلازمة تكيس المبايض في إناث الجرذان . تم تقسيم الحيوانات المتبقية من التجربة الأولى 8 جرذان من مجموعة السيطرة و 32 جرذان من مجموعة تكيس المبايض إلى خمس مجموعات فرعية متساوية بواقع ثمانية جرذان في كل مجموعة على النحو التالي، المجموعة الأولى (السيطرة السلبية): (n=8)جرذان من مجموعة السيطرة المتبقية من التجربة الأولى اعطيت 0.2ml/ جرذ ماء مقطر يوميا عن طريق الفم. المجموعة الثانية (تكيس مبايض): ثمانية جرذان أعطيت 0.2ml/ جرذ ماء مقطر يوميا عن طريق الفم. المجموعة الثالثة (تكيس مبايض + ميتفورمين): أعطيت 50mg/kg من وزن الجسم ميتفورمين عن طريق الفم . المجموعة الرابعة، (تكيس مبايض + مستخلص الحلبة): أعطيت 15mg/kgمن وزن الجسم مستخلص الحلبة يوميا عن طريق الفم. المجموعة الخامسة (تكيس مبايض + ميتفورمين + مستخلص الحلبة): تم إعطاؤها ميتفورمين( 50mg/kg) + مستخلص الحلبة (15mg/kg) من وزن الجسم يوميا عن طريق الفم. واستمرت المعاملة لمدة 21 يوما.تم جمع عينات الدم وتم فصل مصل الدم لاجراء الفحص الهرموني. أظهرت النتائج أن تركيز الهرمون اللوتيني (LH) وهرمون الشحمون الخصوي ( T ) لا يزال أعلى معنويا وتراكيز الايستروجين E2 و والبروجسترون P4 أقل معنويا في مجموعة تكيس المبايض السالبة مقارنة مع مجموعة السيطرة بعد 21 يوما من العلاج. وسجلت درجات معنوية من التحسن في مستوى الهرمونات المذكورة أعلاه في جميع مجموعات المعاملة مقارنة بمجموعتي تكيس المبايض السالبة والسيطرة

Keywords

Fenugreek --- sex hormones --- PCOS --- Letrozole.


Article
Study The Relationship Between Some Sex Hormones and Toxoplasmosis Among Infertile Men Patients in Thi-Qar Province

Authors: Jabbar H. Fezaa --- Mohannad Abd-Al Razzaq Gati --- Bassad A. Al-Aboody
Journal: Journal of Education for Pure Science مجلة التربية للعلوم الصرفة ISSN: 20736592 Year: 2019 Volume: 9 Issue: 2 Pages: 151-157
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

Abstract:Toxoplasma gondii is the causal agent of Toxoplasmosis which infects a large proportion of the world’spopulation, but clinically uncommonly causes significant disease. The present study was performed toestimate the relationship between toxoplasmosis and some sex hormones (testosterone hormone , folliclestimulating hormone (FSH) and luteinizing hormone ) and also to estimate the prevalence of toxoplasmosisin infertility men. 280 samples of both infertile patients(180) and controls(100) had been tested by ELISAtechnique to detect anti-Toxoplasma Abs (IgG and IgM).The levels of sex hormones were also tested inmen sera by ELISA test. The results of the present study in both infertile patients and healthy controlsshowed presence of anti-Toxoplasma IgG Abs in 40 out of 180 (22.23%) and 16 out of 100 (16%)respectively. While the result of ELISA- IgM test was (0 %) in both subjects .The results of sex hormonesappeared the level of testosterone hormone was lowest in infertile patients infected with toxoplasmosiscompared to higher level of hormone in non infected infertile patients and control groups.


Article
Salivary sex hormones & its relation to periodontal status among pregnant & non pregnant women

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Abstract

AbstractSalivary sex hormones (estradiol/ progesterone) levels may rise dramatically &may affect the periodontal health during pregnancy. The aim of this study was tomeasure the level of estradiol &progesterone in stimulated saliva of pregnant women& its correlation to periodontal status in comparison to non pregnant women.A total of 26 women of the age group 20-24yr. attending the maternal & childhealth care in the medical city hospital were selected at the 3rd trimester of pregnancy& another 26 unmarried women were selected rand only. Saliva had been collectedfor analysis of estradiol & progesterone & periodontal status had been evaluated usingplaque index (PlI), gingival index (GI), probing depth (PD) & clinical attachmentlevel (CAL), t-test, X2 & correlation coefficient were used where indicated.The results revealed a significant difference in the mean PlI & GI among pregnant& control groups. Pregnant women showed deeper pocket & more attachment loss &a high mean of salivary sex hormones than control group with significant differences.The results also revealed a positive correlations between probing depth, clinicalattachment level & salivary sex hormones while there was no significant weakcorrelation between PlI, GI with salivary sex hormones.All the periodontal parameter & salivary sex hormones in this study were highervalue in pregnant women than non pregnant with significant differences. More strongpositive correlations were found between PD, CAL with salivary sex hormones &weak correlations with PlI & GI.


Article
ASSOCIATION OF DYSLIPIDEMIA AND OBESITY AFTER MENOPAUSE

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Background: Ageing and hormonal changes in menopause are factors which may play the most important role in the development of all events of this stage of women's life. Of importance in this respect is obesity and related events as insulin resistance, oxidative stress, dyslipidemia and consequent increase in the risk of cardiovascular disease.Objective: To evaluate the association of dyslipidemia with the development of obesity and related events as lipid peroxidation after menopause, and to correlate the different parameters with each other.Methods: Thirty seven premenopausal women aged (33.95±7.9 years) and 41 postmenopausal women aged (59.9±7.2 years) were involved in this study. All were normal and without a previous history of any disease or illness. Blood specimens were collected after 12 hour fast for measurement of serum lipids (total cholesterol TC, Triglycerides TG, and high density lipoprotein cholesterol HDL-C) by enzymatic spectrophotometric methods. Low density lipoprotein cholesterol (LDL-C) was estimated by calculation. The athrogenic index (AI) indicates the ratio of LDL-C to HDL-C, while sex hormones (estradiol, E2, follicle stimulating hormone, FSH and luteinizing hormone, LH) and oxidized LDL (ox-LDL) were measured by ELISA methods. All participants were subjected to anthropometric measurements including body mass Index (BMI) and waist circumference (WC).Results:Marked significant increase in BMI and WC in the postmenopausal women as compared with the premenopausal women and was associated with a significant low E2, high serum TG, TC, LDL-C, AI and ox-LDL with low HDL-C.Conclusion: Changes in serum levels of sex hormones at menopause may be the trigger for the development of post-menopausal obesity, dyslipidemia and elevated Ox-LDL, and that at a given age all these factors should be considered for evaluation of body fat distribution and related health risks. Key Words: menopause, obesity, dyslipidemia, sex hormones, ox-LDL

Keywords

menopause --- obesity --- dyslipidemia --- sex hormones --- ox-LDL


Article
Effect of some chemotherapy drugs) vincristine and vinblastine) on females albino mice fertility and sex hormones level
تاثير بعض ادوية العلاج الكيمياوي (الفنبلاستين والفنكرستين) على خصوبة اناث الفئران ومستوى الهرمونات الجنسية

Author: Hazim I. A. Al-Ahmed حازم اسماعيل عبد الباري الاحمد
Journal: Jornal of Biotechnology Research Center مجلة مركز بحوث التقنيات الاحيائية ISSN: 18151140 Year: 2010 Volume: 4 Issue: 2 Pages: 91-97
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The aim of this study was to determine the effect of chemotherapy (vincristine and vinblastine) on the fertility and sex hormones level of female mice. Twenty four female albino mice were divided into three equal groups. The First group injected with vincristine 0.05 mg/kg intraperitoneally daily for 3 weeks. The second group injected with vinblastine 0.05 mg/kg intraperitoneally daily for 3 weeks. The third group treated with normal saline intraperitoneally daily for 3 weeks as control group. Blood samples were collected by using heart puncture within plastic syringes and transferred to plastic tubes. Blood centrifuged and serum was harvested for hormonal assay. The animals in each group were killed by dislocation of cervical vertebrate in third week of the treatment. Ovaries weighed and fixed with Bouin solution for histological study. Results showed significantly (P<0.05) decreased in ovaries weight on groups treated with vincristine and vinblastine as compared with control group. The mean numbers and diameters of primary, secondary follicles and corpus luteium, and hormones level [follicular stimulating hormone (FSH), lutenizing hormone (LH), estrogen and progesterone] were significant declined in groups treated with vincristine and vinblastine as compared with control group. Results indicated that fertility and sex hormones level reduced in females treated with chemotherapy drugs vincristine and vinblastine

هدفت الدراسة الحالية الى معرفة تاثير بعض ادوية العلاج الكيمياوي (فنكرستين و فنبلاستين) على ، خصوبة اناث الفئران ومستوى الهرمونات الجنسية فيها . استخدمت في هذه الدراسة 24 انثى من الفئران قسمت الى 3 مجاميع متساوية ، حقنت المجموعة الاولى بالفنكرستين 0.05 ملغم/كغم داخل الخلب البريتوني يوميا لمدة ثلاثة اسابيع . اما المجموعة الثانية فقد حقنت بالفنبلاستين 0.05 ملغم/كغم داخل الخلب البريتوني يوميا لمدة ثلاثة اسابيع . في حين حقنت المجموعة الثالثة بالمحلول الملحي الفسيولوجي كمجموعة سيطرة داخل الخلب البريتوني يوميا لمدة ثلاثة اسابيع . تم جمع نماذج الدم عن طريق ثقب القلب بواسطة محاقن بلاستيكية ووضعت في انابيب بلاستيكية في جهاز الطرد المركزي للحصول على المصل لغرض قياس الهرمونات . تم قتل جميع الحيوانات عن طريق فصل الرقبة بعد الاسبوع الثالث من التجريع ، وزنت المبايض ووضعت في سائل باون لغرض اجراء الدراسة النسيجية . اظهرت النتائج انخفاض معنوي (P<0.05) في معدل اوزان المبايض في المجاميع المعاملة بالـفنكرستين والفنبلاستين مقارنة مع مجموعة السيطرة . وكذلك انخفضت معدلات اعداد واقطار الجريبات الاولية والثانوية والاجسام الصفراء ، ومستوى الهرمونات في الدم (الهرمون المحفز للجريبات والهرمون اللوتيني والاستروجين والبروجستيرون ) في المجاميع المعاملة بالـفنكرستين والفنبلاستين مقارنة مع مجموعة السيطرة . اظهرت نتائج الدراسة ان الاناث المعاملة بادوية العلاج الكيماوي بالفنكرستين والفنبلاستين قد انخفضت خصوبتها و مستوى الهرمونات الجنسية لديها .


Article
Clinical Management of an Unusual Case of Gingival Enlargement

Author: Dr. Barzan Abdulwahab Atrooshi, B.D.S M.Sc.* د. برازن عبد الوهاب
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2008 Volume: 5 Issue: 4 Pages: 429-433
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The purpose of this article is to report a case of conditioned gingival enlargement managed by non surgical periodontal therapy. Hormones are specific regulatory molecules that modulate a host of body functions. Hormonal effects reflect physiologic and pathologic changes in almost all tissues of the body with the periodontium being no exception. Physiologic changes like puberty, the menstrual cycle, and pregnancy cause hormonal variations that may cause inflammation of the gingiva. Oral contraceptives that contain estrogen and/or progesterone are associated with gingival enlargement.A 28-year-old female presented with a complaint of swelling of the gingiva with spontaneous bleeding in the maxillary anterior region for a period of one year. The health history documented the use of contraceptives for one year, and a clinical examination revealed the existence of poor oral hygiene and enlarged painful gingival tissues that bleed when touched.This case reaffirms the fact plaque control is the most important procedure in any periodontal therapy. Another factor contributing to the excellent response to therapy is patient compliance. The patient followed home care instructions well and was effective in personal oral hygiene measures.

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