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Epidemiology of toxoplasmosis among Samarra' University female students and effect of infection on some sexual hormones
انتشار داء المقوسات لدى بعض طالبات جامعة سامراء مع تأثير الخمج على بعض الهرمونات الجنسية

Author: Marwa Jasim Mohammad مروة جاسم محمد
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2018 Issue: 14 Pages: 120-130
Publisher: Kerbala University جامعة كربلاء

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Abstract

The current study aimed to determine the epidemiological infection of toxoplasma gondii and learn their prevalence toxoplasmosis among Samarra' University female students, As well The study focused on highlighting some factors such as social status Contact with cats and the effect of infection on testosterone and progesterone. We could get (100) samples of the blood of female students, ranging in age between (19 - 27) years. The blood was separated and stored in the refrigerator at a temperature of -20 ° C until the examination. The samples were examined by detecting antibodies by latex antibody test and 53% were positive. Then positive resulting in latex were examined in cobas e 411, Germany, was established to detect IgM and IgG antibodies and the proportions were 22.6% and 77.4%, respectively. The samples were divided into (4) groups of each group containing (25) samples. The first group included single women, the second group were married (without pregnancy), the third group was pregnant and the fourth group was abortions. The results showed that the infection rate was 16.9, 24.6, 18.8, 39.7%, respectively. In the case of direct contact with animals, especially cats, the highest rate of infection when contact with cats was 77.4%. The results of the statistical analysis at P ≤ 0.05 showed significant differences in testosterone at a rate of 0.813 ng / ml. And progesterone hormones at a rate of 19.130 ng / ml in pregnant women with toxoplasmosis compared to control group.

هدفت الدراسة الحالية الى تحديد وبائية الاصابة بالمقوسات الكونيدية Toxoplasma gondii ومعرفة نسبة انتشارها لدى طالبات جامعة سامراء، فضلا عن ذلك اهتمت الدراسة بتسليط الضوء على بعض العوامل كالحالة الاجتماعية ووجود تماس مع القطط وتأثير الخمج على هرمون التستوستيرون والبروجستيرون . لقد امكن الحصول على (100) عينة من دم الطالبات والتي تراوحت اعمارهن ما بين ( 19 - 27 ) سنة. وتم فصل الدم وحفظ في الثلاجة بدرجة حرارة (– 20 درجة مئوية ) الى حين اجراء الفحص. حيث تم فحص العينات عن طريق الكشف عن الاضداد بواسطة اختبار اللاتكس للاجسام المضادة وكانت النسبة 53% اصابة موجبة . ثم فحصت الاصابات الموجبة الناتجة من فحص اللاتكس بجهاز cobas e 411 الالماني المنشأ للكشف عن الاضداد من نوع IgM و IgG وكانت النسب 22.6% و 77.4% على التوالي . كما تم تقسيم العينات الى (4) مجاميع كل مجموعة تحتوي على (25) عينة. تضمنت المجموعة الاولى طالبات عازبات، والمجموعة الثانية متزوجات (بدون حمل) ، المجموعة الثالثة حوامل والمجموعة الرابعة مجهضات، حيث اظهرت نتائج الفحص ان نسبة الاصابة كانت 16.9%، 24.6%، 18.8%، 39.7 % على التوالي. وعند اخذ حالة التماس المباشر مع الحيوانات وخاصة القطط كانت اعلى نسبة للإصابة عند وجود تماس مع القطط بنسبة 77.4 % . كما اظهرت نتائج التحليل الاحصائي عند مستوى احتمالية 0.05P ≤ وجود فروق معنوية في هرمون التستوستيرون بمعدل 0813 ng/ml وهرمون البروجسترون بمعدل 19.130 ng/ml لدى النساء الحوامل المصابات بداء المقوسات مقارنة بمجموعة السيطرة.


Article
Combination of atorvastatin and fenofibrate altered androgenic activities of male rats

Authors: Kawa F. Dizaye --- Sundus Rashad Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2019 Volume: 23 Issue: 2 Pages: 273-282
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Many drugs and chemical substances may induce sexual dysfunction and have a negative impact on male fertility. Lipid-lowering agents like statins and fibrates are usually recommended for cardiovascular diseases prevention. However, the combination of atorvastatin and fenofibrate is the subject of questions concerning their effect on androgenic activities in this study. This study was designed to evaluate the efficacy and toxicity of atorvastatin, fenofibrate, and their combination on sperm parameters, sexual hormones, and histopathology of the testis. Methods: Twenty-four male rats were divided into four groups, each of six. The first group served as a control. The second, third, and fourth groups received atorvastatin, fenofibrate, and their combination, respectively. After 28 days, blood samples were collected for hormones and other parameters evaluations. Testis and epididymis were taken for histopathology studies and sperm parameters assessments.Results: Fenofibrate showed a significant reduction in sperm viability and serum levels of luteinizing and estradiol hormones. The combination of both drugs significantly reduced the sperm count and viability in normal male rats. Both atorvastatin and its combination mildly changed the histological structures of the testis, reduced number of spermatozoa, and arrested spermatogenesis.Conclusion: The findings from this prospective study suggested that there was no harmful effect of atorvastatin usage on conventional sperm parameters and sexual hormones. Fenofibrate usage was not adversely associated with sperm parameters other than sperm viability. The combination of atorvastatin and fenofibrate significantly reduced the sperm count and viability. No deleterious effects of the drugs were seen on the testosterone, which was the essential hormone for all stages of spermatogenesis, sperm production, maturation, and transport.

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