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Evolution of the Effectiveness of Peremetherin and Trimethoprim/ Slfomethoxazole on Pediculosis Capitit and some Bacteria Isolated from its Complication
تقييم تاثير البيرميثرين وترايمثوبريم مثاكسوزول على قمل الراس وبعض الابكتريا المعزوله من مضاعفاتها

Authors: Burooj Mohammed Razooqi2 بروج محمود رزوقي --- Khudhair Khalf Al-Kayalli خضير خلف الكيالي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2017 Volume: 30 Issue: 2 Pages: 79-82
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract: Background:Head lice infestation caused by Pediculus humanus var. Capitis, is the most prevalent human ectoparasitic disease worldwide, head lice are haematophagous, frequent among children 3-11 years. Traditional pharmacological therapies, have focused on 1 or 2 courses of various ovicidal and pediculicidal topical therapies. Objectives: To compare the effectiveness of permetherin and trimethoprim/sulfamethoxazole on 1 or 2 courses of various ovicidal and pediculicidal topical therapies. Methods; Seventy five females patients with pediculosis capitis , their ages ranged from 3 to 60 years. In 40 patients the pediculosis was complicated by secondary bacterial infection. The patients were divided in to three groups, Group 1 :-The patients were treated by 5% permetherin solution . Group 2 :-Was treated by trimethoprim /sulfamethoxazole tablet or solution according to the age .Group 3:- Was treated by combination of 5% permetherin solution and oral trimethoprim /sulfamethoxazole . Swabs were taken from patients with bacterial infection.Results:The study revealed that 23(92%) patients of the first group, was cleared, 20(80%)patients from the second group, also cleared and all the patients in the third group 25(100%). Of those who were complicated by secondary bacterial infection 40(60%), 30(75%) the cultures show bacterial growth. The cultures which were tested by 5% permetherin shows no inhibition zone but those cultures which were tested by trimethoprim /sulphamethoxazol shows significant inhibition zone.Conclusion:It was concluded that permetherin was ineffective as antibacterial agent but it was highly effectivas pediculocidal agent and it was more effective when combined with oral trimethoprim/ sulfamethoxazole.


Article
The Effect of Interference between Honey and Antibiotic on some Biological Features to Staphylococcus aureus
تأثير تداخل العسل مع المضادات الحيوية على بعض الصفات البيولوجية لبكتريا المكورات العنقودية الذهبية

Author: Hamdi A. Naeef ** Laith M. Najeeb ** Noor M. Taher حمدي عبد الله نايف **ليث مصلح نجيب **نور محمد طاهر
Journal: ANBAR JOURNAL OF AGRICULTURAL SCIENCES مجلة الأنبار للعلوم الزراعية ISSN: PISSN: 19927479 / EISSN: 26176211 Year: 2013 Volume: 11 Issue: 2 Pages: 400-406
Publisher: University of Anbar جامعة الانبار

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Abstract

In the Study we investigate the effectiveness of interference between honey and antibiotics to Staphylococcus aureus, which one of the most resistant pathogens to antibiotics, and study there sensitivity forward 16 antibiotic and consecutive concentrations of honey, in addition to the interference between honey and antibiotics, and study the effect of honey on total lipids in bacterial cells. The results of sensitive test shown that, the isolation display variance response to antibiotics which used in this experiment, and also proved the high sensitivity of the isolation toward antibiotics like: Clindamycin, Amikacin and Ciprofloxacin, the most influential antibiotic with inhibition diameters 28, 21 and 20 mm, respectively. Increasing sensitivity of isolation in direct correlation with the increasing concentration of honey, and the isolation have recorded the maximum inhibition diameter 16.5 mmdisk in concentration 50% of honey, and when examining the interference between honey and antibiotics, results showed evident disparity in their sensitivity to the treatment, depended antibiotic type and honey concentration . In general the antibiotics activity increasing when the honey concentration is increase for example , the bacterial isolate became sensitive to Amoxillin clavulanic acid in diameters range between 31 and 34 to the treatment of antibiotic and honey wile , the isolate was resist to treatment of antibiotic alone . On the other hand the result showed effect of honey to change the total lipids, the honey decreasing the lipids in the bacterial cells opposition with concentration of Honey

اجريت الدراسة للتحري عن فعالية تداخل العسل والمضادات الحيوية تجاه المكورات العنقودية الذهبية المعزولة من الجروح والحروق, والتي تعد من اكثر المسببات المرضية مقاومة للمضادات, اذ درست حساسية البكتريا 16 مضاداً حيوياً ولتراكيز متتالية من العسل بالإضافة الى التداخل بين العسل والمضادات, ودراسة تأثير العسل على المحتوى الدهني في الخلايا البكتيرية. لقد بينت نتائج فحص الحساسية الاختلاف الملحوظ في درجة استجابة العزلة للمضادات الحيوية المستخدمة في هذه التجربة, وأثبتت النتائج الحساسية العالية للعزلة تجاه المضادات Clindamycin, Amikacin و Ciprofloxacin فهي الاكثر تأثيراً على العزلة بأقطار تثبيط بلغت 28 و21 و20 ملم على التوالي. اظهرت العزلة حساسية متزايدة وبصورة طردية مع ازدياد تركيز العسل, اذ سجلت العزلة اعلى قطر تثبيط 16.5 ملمقرص عند التركيز50%, وعند دراسة التداخل بين العسل والمضادات بينت النتائج ان العزلة اظهرت تباين بحسب نوع المضاد وتركيز العسل, وبشكل عام تزداد فعالية المضادات بزيادة تركيز العسل فمثلا اصبحت العزلة حساسة لمضاد Amoxillin clavulanic acid (AMC) وبأقطار تراوحت بين 31- 34 عند تداخل العسل مع المضاد بعد ان كانت مقاومة له.من جانب اخر أظهرت نتائج الكشف عن دور العسل في تغير المحتوى الدهني, ان العسل يعمل على تقليل ذلك المحتوى وبصورة عكسية فكلما زاد التركيز قلت الدهون الكلية في الخلايا البكتيرية.

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