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Article
Renal Involvement in 25 Patients with Systemic Sclerosis

Authors: Nizar Abdulateef Jassim --- Ziad Shafeek Al-Rawi --- Ali Abdumajeed Diab --- Ali Nazar Mohammed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 1 Pages: 1-6
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Renal involvement is considered a poor prognostic factor and not frequently a cause of death in patients with scleroderma. Renal involvement can be divided into scleroderma renal crisis and non-renal crisis abnormalities.OBJECTIVE:To evaluate the frequency of renal involvement in 25 Iraqi patients with systemic sclerosis (SSc).METHODS:Twenty five patients with SSc (21 female and 4 male) were included in a case-controlled study. All patients fulfilled the American College of Rheumatology criteria for SSc. All patients were of diffuse type. Other types of SSc were excluded. All patients underwent measurement of blood pressure and investigations had been done for them which included: hemoglobin (Hb), white blood cell (WBC) count, platelet count, erythrocyte sedimentation rate (ESR), blood urea (BU), serum creatinine (SCr), general urine examination (GUE), and rheumatoid factor (RF). Same investigations were done for 25 healthy person (considered as control group).RESULT:All patients (100%) had Raynaud’s phenomenon, 23 patients (29%) had dysphagia, 21 patients (84%) had arthralgia, 10 patients (40%) had telangiectasia and 2 patients (8%) had subcutaneous calcification. Three patients (12%) had moderate hypertension. Fourteen patients (56%) had anemia, 2 patients (8%) had leukocytosis, 6 patients (24%) had elevated ESR, 1 patient (4%) had elevated BU, 1 patient (4%) had albuminuria and 4 patients (16%) had positive RF. Platelet count and SCr were normal in all patients. Only 1 patient (4%) had renal involvement in form of combination of azotemia, albuminuria and hypertension.CONCLUSION:Renal involvement in systemic sclerosis among Iraqi patients is rare.

Keywords

renal --- iraqi --- systemic sclerosis.


Article
A Novel Study of Predictive Utility of Serum Melatonin in Diagnosis of Systemic Sclerosis: A Case-Control Study

Author: Faiq I. Gorial
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2017 Volume: 16 Issue: 3 Pages: 224-228
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Melatonin is a pineal gland hormone with complex roles in the pathogenesis of autoimmune disorders. Immune abnormalities and disturbed endocrine secretion have been reported in patients with systemic sclerosis (SSc). A possible role of melatonin in pathogenesis of SSc patients might be presentOBJECTIVE: To assess the predictive utility of serum melatonin in diagnosis of SSc patients.METHODS: A case-control study conducted at Rheumatology Unit of Baghdad Teaching Hospital-Medical City from November 2015 to April 2016 on 40 SSc patients diagnosed according to the 1980 criteria for classification of systemic sclerosis or 2013 American College of Rheumatology/European League Against Rheumatism for the classification of systemic sclerosis criteria and compared with 40 healthy controls matched in age, sex, and body mass index. Patients with overlapping other inflammatory arthritis or connective tissue disease or autoimmune diseases were excluded. Serum melatonin was measured in both groups by enzyme-linked immunosorbent assay (ELISA). RESULTS: Mean level of serum melatonin concentration was significantly lower in patients compared with controls (Mean ± SEM of patients was 602.9 ± 30.69 vs 782.1 ± 43.66 pg/ml for controls, p=0.001). The optimum cut-off value of serum melatonin that differentiate between patients and controls was ≤ 810.8 pg/ml (AUC=0.72, p=0.0005). Validity of serum melatonin at the optimum cutoff value showed highest level of accuracy (75%) with sensitivity 87.5% and specificity 62.5% and if the test was positive and the clinical suspicion of prestest probability was 50% then we have 70% confidence that the patient has systemic sclerosis [ Positive predictive value (PPV) at pretest 50%=70%]. However, this confidence will increase to 95.5% if the clinical suspicion of pretest probability was 90% (PPV at pretest probability 90%=95.5%). Also, if the test was negative then we can exclude the disease with 97.8% with confidence [Negative predictive value (NPV) =97.8%].CONCLUSION:Serum melatonin was a valid measure to diagnose SSc.


Article
Evaluation of Anti-Centromere Antibodies, Anti-SSA and Anti-SSB in Serum and Saliva of Patients with Systemic Sclerosis

Authors: Taghreed F. Zaidan --- Mohassad H Al-Mudhaffar
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 3 Pages: 17-20
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Systemic sclerosis (SSc) is a chronic autoimmune illness, which is consider by three main features: Sclerotic changes in the skin and internal organs, Vasculopathy of small blood vessels, Particular autoantibodies (1). The most important autoantibodies appeared significantly in SSc patients are anti-topoisomerase I autoantibody (Scl-70), anti-centromere autoantibody (ACA), and anti-RNA polymerase III autoantibody (RNAP3) (2). Anti-centromere antibodies (ACA) are infrequent in rheumatic conditions and in healthy persons but occur commonly in limited systemic sclerosis (CREST syndrome), and rarely appeared in the diffuse form of systemic sclerosis (3). Anti-Ro/SSA and antiLa/SSB, antibodies directed against Ro/La ribonucleoprotein complexes, can serve as a diagnostic hallmark of autoimmune disease specially Sjogren’s syndrome (4).Materials and methods: This study was carried out during the period from the middle of November 2015 until the end of November 2016 in Baghdad city. The sample of this study was divided into two groups : Forty systemic sclerosis patients: Those patients were treated at Rheumatology department in Baghdad teaching hospital in Baghdad city as well as Forty healthy control subjects, age matched with no signs and symptoms of any systemic diseases.Results: The serum anti-SSA in SSc patient was significant increased as well as the salivary anti-SSA in SSc patient was highly significantly increased than in the control subjects by using t-test. The present study found that there no statically difference in salivary ACA, anti-SSB and serum anti-SSB while serum ACA was significantly increased.Conclusions: autoantibodies play a role in pathogenesis of SSc patients represented by increased serum (ACA and anti-SSA) that it considered reliable indicator for SSc patients while unpredicted marker in saliva except anti-SSA. Anti-La/SSB is unreliable marker in both serum and saliva SSc patients. The presence of Anti-Ro/SSA antibodies in serum and saliva of SSc patient has been predictive marker for SSc overlapped Sjogren’s syndrome.


Article
Pulmonary changes findings in patients with systemic sclerosis by high resolution computed tomography
رئوي التغييرات في نتائج مرضى التصلب الجهازي بواسطة التصوير المقطعي ارتفاع القرار

Author: Sameer K. Muhammad سمير خيرالله محمود
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2009 Volume: 1 Issue: 151 Pages: 117-123
Publisher: Tikrit University جامعة تكريت

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Abstract

This study was done to assess the ability of high resolution computed tomography (HRCT) in detecting the early signs of pulmonary involvement in patients with systemic sclerosis (SSc). The chest in ten patients with established diagnosis of SSc according to American College of Rheumatology criteria for classification of systemic sclerosis-1980 were examined by conventional chest x-ray (CXR) at Tikrit teaching hospital,(2007-2008) . After that, each patient was subjected to chest HRCT. The finding in HRCT imaging seen in nine patients (90%), while only five patients (50%) showed an abnormality on conventional CXR suggestive of an interstitial lung disease and/or chronic pulmonary fibrosis. The HCRT findings were distributed among the reticular and nodular structures (70%), decreased opacity (70%) and other accompanying lesions seen in (60%) of patients. No one of the examined group showed a sign of increased opacity which include the sign of ground glass appearance. HRCT scanner considered a worthfull imaging modality in all patients with SSc, especially at an early stage of the disease as the management of the pulmonary complication in such patients is more effective when applied early

This study was done to assess the ability of high resolution computed tomography (HRCT) in detecting the early signs of pulmonary involvement in patients with systemic sclerosis (SSc). The chest in ten patients with established diagnosis of SSc according to American College of Rheumatology criteria for classification of systemic sclerosis-1980 were examined by conventional chest x-ray (CXR) at Tikrit teaching hospital,(2007-2008) . After that, each patient was subjected to chest HRCT. The finding in HRCT imaging seen in nine patients (90%), while only five patients (50%) showed an abnormality on conventional CXR suggestive of an interstitial lung disease and/or chronic pulmonary fibrosis. The HCRT findings were distributed among the reticular and nodular structures (70%), decreased opacity (70%) and other accompanying lesions seen in (60%) of patients. No one of the examined group showed a sign of increased opacity which include the sign of ground glass appearance. HRCT scanner considered a worthfull imaging modality in all patients with SSc, especially at an early stage of the disease as the management of the pulmonary complication in such patients is more effective when applied early

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