This study shows the effects of Testosterone hormone on uterus tissue in female mice. We used twenty laboratory mice (Ten animals for each group). The first groups used as a control by using physiological saline (0.9%) concentration. The second groups were taken the 10mg/kg for 28 days. Biopsy was taken from the animals to examine their tissue histopathologically, Results were seen in uterus form of degradation in Endometerium and bleeding .Deteriorate in epithelial tissue and infiltration in inflammatory cells .

أجزيج هذ انذراست ن عًزفت حأريز هزيى انخيسخىسخيزو عهى سَيج انزدى في إ بَد انفئزا حى اسخخذاوعشزو ي أ بَد انفئزا ان خًخبزيت حى حقسي هًب عشىائيب انى يج ىًعخي )عشزة نكم يج ىًعت ( اعخبزث ان جً ىًعتالأونى يج ىًعت سيطزةوديذ دق جُ ببن ذًهىل انفسيىنىجي أيب ان جً ىًعت انزب يَت فقذ دق جُ بهزيى انخيسخىسخيزو 10 يهغى/كغى ي وس انجسى ون ذًة ر بً يَت وعشزي يىيب حى انخضذيت ببنذيىا بَث في هَبيت انخجزبت وأخذث ي هُبعضى انزدى نع مً ان قًبطع ان سُجيت وح زًهج انعلايبث ان زًضيت في سَيج انزدى نفئزا ان جً ىًعت انزب يَت بذصىلدبنت انخذهم في انطبقت ان بًط تُ نهزدى يع دبنت ان شُف وكذنك دبنت انخهف نهطبقت انطلائيت يع دبنت أرحشبح نهخلايبالانخهببيت

Testosterone --- uterus --- female mice

This study was carried out during the period 25/1/2017 to 20/3/ at AL-Sader Teaching Hospital in Najaf 2018, to investigate the effects of the relationship between the leptin hormone and infertile men, leptin hormone and two hormone (insulin and testosterone ) and some demographic factors as age, weight, height and body mass index on leptin hormone. Fifty blood samples from infertile men and forty blood samples from fertile men were classified in to three aging groups ranged (20-35),(36-45) and (46-55) years ,the values of hormones (leptin ,insulin and testosterone) were examined to find out the correlation between hormone with each other and with infertile men. Significant differences were detected between (p≤0.05) in insulin and leptin levels. Besides significant reductions at (p≤0.05) in testosterone levels confined to age groups (20-35) and (36-45) in infertile men, as compared to fertile men. The result also revealed a positive relationship (p≤0.05) between the body mass index and leptin hormone.

اجريت الدراسة الحالية في مستشفى الصدر التعليمي في النجف من 25/1 /2017-20/3/2018 لتحقيق العلاقة بين هرمون اللبتين والعقم لدى الرجال , هرمون البتين مع هرموني الانسولين والتستوستيرون , و بعض العوامل الديموغرافية مثل العمر ,الطول ,الوزن و مسعر كتلة الجسم الذي يأثر على هرمون اللبتين. خمسون عينة دم اخذت من الرجال الذين يعانون العقم واربعين عينة دم من الذكور الطبيعيين حيث استخدمت في هذه الدراسة التي صنفت الى فئات عمرية تتراوح (20-35),(36-45) و (46-55) سنة , قيم هرمونات (اللبتين و انسولين وتستوستيرون) حيث فحصت لتبين العلاقة بين الهرمونات مع بعضها ومع الرجال العقيمين , النتيجة بينت وتم فحص هرمون اللبتين ,اظهرت النتائج فروق معنوية بين القيم المتمثلة بواسطة زيادة معنوية (p≤0.05) في مستوى اللبتين والانسولين و انخفاض معنوي(p≤0.05) في مستوى التستوستيرون عند الفئات العمرية (20-35) و (36-45) في الرجال العقيمين عند مقارنة مع الرجال الخصيبين , وكشفت النتائج علاقة موجبة (p≤0.05) بين مسعر كتلة الجسم وهرمون اللبتين .

Infertility --- Leptin --- Insulin --- Testosterone

Background and objective: Obesity has been associated with increased androgenicity in women. There are, however, major inconsistencies in available data concerning the possible association between androgenicity and leptin in humans.The objectives of this study were to evaluate the impact of body mass index on androgens and the potential contribution of leptin in determination of androgen levels in women.Methods: The study included 80 healthy females with an established Body Mass Index (BMI). They were divided into 4 groups. First group, 30 normal weight subjects (BMI<25 Kg/m2), second group, 25 overweight subjects (BMI=25–29.9 Kg/m2) , third group,15 obese grade-I subjects (BMI=30–34.9 Kg/m2) and forth group, 10 obese grade-II subjects (BMI>35 Kg/m2). Serum, leptin, free testosterone, androstenedione, glucose, lipid profile and body mass index were measured.Results: There was no statistically significant difference in median serum androstenedione, while free testosterone was significantly lower (14.5 pg/ml) in obese grade II and higher in normal weight (60 pg/ml) and statistically significant increase in serum leptin with increase in body mass index. Serum free testosterone was lower (23.5 pg/ml) in subjects with highest quartile serum leptin and higher (43pg/ml), in subjects with lowest quartile serum leptin, the difference was not significant statistically.Conclusion: high body mass index negatively influence the circulating free testosterone in reproductive age women. An inverse association between circulating leptin and free testosterone was observed

androstenedione --- leptin --- free testosterone

Objective : to find out the relationship of zinc concentrations in blood and serum testosterone concentrations with various semen parameters between fertile and infertile men .Design : prospective study Setting : this study was carried out in infertility clinic of Al – Batool teaching Hospital in Mosul .Subjects and Methods : one hundred infertile male subjects without any treatment aged 25 – 50 years , were selected from infertility clinic at Al – Batool Teaching Hospital. After semen analysis they were grouped as oligospermic. Fifty known fertile male selected from general population and after semen analysis they were taken as normospermic control group . Blood samples were taken from each subject in the morning for serum zinc and testosterone estimation. Serum zinc was estimated using atomic absorption , serum testosterone was was estimated using minividus technique .Result : Anon – significant negative correlation between serum zinc and semen volume in infertile subjects was found , while a significant positive correlation was found between serum zinc and sperm count ,motility, morphology and serum testosterone. Also we found that serum zinc level and serum testosterone level were significantly lower in infertile men as compared to control men. Conclusion : on the basis of the findings of this study and those of other reports , zinc may contribute to fertility through its significant effects on various semen parameters and testosterone concentrations . It seems that the estimation of serum zinc may help in investigation and treatment of infertile

اهداف البحث : لمعرفة العلاقة بين مستوى الزنك في الدم ومستوى هورمون التستوستيرون في الدم وكذلك مستوى الزنك في الدم مع خصائص المني المختلفة للرجال العقيمين والرجال الخصبين . التصميم : دراسة مستقبلية .مكان اجراء البحث والاطار الزمني له : اجري البحث في عيادة العقم في مستشفى .البتول التعليمي في الموصل للفترة من نيسان 2009 –تموز 2009 .الطرق المتبعة : اجريت فحوصات السائل المنوي وقيلس مستوى الزنك في الدم وقياس مستوى هورمون التستوستيرون في الدم لمئة من الرجال العقيمين اللذين تتراوح اعمارهم بين 25 – 50 سنة تم اختيارهم من عيادة العقم في مستشفى البتول التعليمي في الموصل وخمسون من الرجال الخصبين تم اختيارهم من عامة الناس كعينة سيطرة .النتائج : اظهرت هذه الدراسة انخفاض في مستوى الزنك في الدم وانخفاض في مستوى التستوستيرون في الدم لدى الرجال العقيمين عندما تمت مقارنتهم مع الرجال الخصبين (عينة السيطرة) .كما لوحظ ارتباط سلبي غير معنوي بين مستوى الزنك في الدم وحجم السائل المنوي لدى الاشخاص العقيمين بينما لوحظ ارتباط ايجابي بين مستوى الزنك في الدم ومستوى هورمون التستوستيرون في الدم وكذلك ارتباط ايجابي بين مستوى الزنك في الدم وعدد النطف وحركة النطف وشكل النطف .الاستنتاج : على اساس ما توصلنا اليه في هذه الدراسة من الممكن اعتبار عنصر الزنك له علاقة بالخصوبة من خلال تاثيراته على خصائص المني ومستوى هورمون التستوستيرون ويبدو ان قياس مستوى الزنك ممكن ان يساعد في تشخيص ومعالجة الرجال العقيمين .

serum zinc --- oligospermic --- infertility --- testosterone

Background; Insulin resistance and increased serum free testosteroneare well known to be associated with preeclampsiaType of study; case controlAim of the study; to compare serum levels of free testosterone amonghypertensive preeclamptic women versus controlMethods; two groups were constructed from primigravida womentaken from labor ward. Study group (N=30) were preeclamptic versuscontrol (n=30). For all women serum testosterone was assayed andcompared and correlated to mean arterial blood pressure and othervariables in preeclampsiaResult; serum free testosterone was significantly higher among womenwith preeclampsia compared with control 5.00±0.72 versus 1.28±0.97, P< 0.001. No Significant change was found between serum estriol levelsin both groups. Analysis of co-variants has shown that fetal gender(Male) has no effect on maternal serum testosterone levels.Conclusions; preeclamptic women in the third trimester havesignificantly higher free testosterone serum levels than control women.It is not clear yet whether this increase in free testosterone is related toinsulin resistance in the placenta or other factors. Further studies arerequired to explore the significance of increased testosterone levels inthe blood with prediction of preeclampsia and assessment of itsseverity.

free testosterone --- preeclampsia --- insulin resistance